>Interleukin Protein Families
Interleukins (ILs) is a term that describes a group of secreted molecules produced by leukocytes that act on a variety of cells. Generally, ILs are classified as cytokines, but are also a member of the lymphokines family. ILs have diverse biological functions; not only is it involved in regulating immune response such as promoting the information transmission, activation and regulation of immune cells, but also is widely involved in regulating the physiological and pathological processes of the body such as autoimmune, inflammatory and tumor diseases. Based on the structural homology of cytokines, interleukins are divided into several protein families, such as IL-1, IL-2, IL-6, IL-10, IL-12, and IL-17 families.
It is worth noting that, the interleukin family has emerged as a significant drug target, many of which are already on the market and even occupy a significant market share of drugs for similar diseases.
Biotinylated Human IL-1 RAcP, His,Avitag (Cat. No. ILP-H82E5) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 90%. As verified by SEC-MALS, the purity is more than 90% and the molecular weight of this protein is around 50-68 kDa.
Human IL-2RB&IL-2RA&IL-2RG, Fc Tag&Fc Tag (Cat. No. ILG-H5257) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%. As verified by SEC-MALS, the purity is more than 90% and the molecular weight of this protein is around 160-190 kDa.
Human IL-31, His Tag (Cat. No. IL1-H5247) capture on NTA-Series S sensor chip can bind Human IL-31 RA, Fc Tag (Cat. No. ILA-H5256) with an affinity constant of 37.1 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Human IL-13 R alpha 1 Protein, His Tag (Cat. No. IL1-H5224) captured on CM5 chip via anti-His antibody can bind Human IL-13 with an affinity constant of 16 nM as determined in a SPR assay (Biacore T200) (QC tested).
Loaded Biotinylated Human IL-6, epitope tag free, primary amine labeling (Cat. No. IL6-H8218) on SA Biosensor, can bind Human IL-6 R alpha, His Tag (Cat. No. ILR-H4223) with an affinity constant of 45.9 nM as determined in BLI assay (ForteBio Octet Red96e).
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