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Your Position: Home > Hemagglutinin (HA)

Hemagglutinin (HA)

Brief Information

Name:Influenza virus hemagglutinin glycoproteins
Target Synonym:Hemagglutinin,HA,Hemagglutinin Glycoproteins, Influenza Virus
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Synonym Name

HA,Hemagglutinin

Background

Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Hemagglutinin also plays a major role in the determination of host range restriction and virulence. As a class I viral fusion protein, hemagglutinin is responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Anti-influenza monoclonal antibody (AIMM Therapeutics) Phase 1 Clinical Aimm Therapeutics Influenza, Human Details
Influenza vaccine quadrivalent (Nitto/Osaka) NSV-0001 Osaka University, Nitto Denko Details
Gedivumab RG-7745; MHAA-4549A Genentech Inc Details

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