Pre-formed fibrils are an invaluable preclinical model for exploring pathogenesis of neurological diseases through aggregation of misfolded proteins. Explore our pre-seeded PFFs to use in your research.
Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. Explore our series of recombinant neural factors to support the culture and differentiation of nerve cells.
Partnering with Diagnostic Biochips, we now provide solutions for in vivo electrophysiology recordings, including high-quality multi-channel electrodes and other products to facilitate high-quality, efficient analysis of neural circuit structure and function.
Protein markers are an essential component in biological research and drug development. Whether it is for protein electrophoresis or western blot, our pre-stained protein markers help you quickly determine the molecular weight of the target protein or evaluate the transfer efficiency.
Streptavidin is a tetrameric protein providing 4 high-affinity biotin binding sites. We offer a wide array of products pre-conjugated with streptavidin to support your research as well as biotinylated proteins.
Setting the corresponding isotype control antibody to detect non-specific binding can reduce the generation of false positive results and evaluate the possible influencing factors accurately in the drug development process. Explore our isotype controls for your research.
The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. Explore our comprehensive collection of recombinant Fc receptor proteins!
Organoids are three-dimensional tissue structures composed of a variety of cell types. Through in vitro 3D cell culture, they can continually be expanded in vitro for a long time and retain the key characteristics of organs. It can simulate the architectural and functional characteristics of human organs and even the tumor microenvironment. With recent advancements in organoid culture and the elucidation of growth factors needed to direct cell differentiation, organoids have become an indispensable tool in the process of drug development and evaluation. Currently, most organs in the human body can be formed into organoids in vitro, reproducing the cellular milleau of liver, lung, heart, blood vessels, and many others. As such, organoids have the potential to become an essential preclinical model for human disease research and drug development.
To support research on organoid cell culturing, ACROBiosystems has developed a series of high-quality cytokines, including EGF, Noggin, R-Spondin 1, BDNF, GDNF. These products are suitable as growth factors for organoid culture that have been verified to promote organoid growth.
Verified by multiple organoid culture, excellent performance and superior to competitors
The organoid culture cytokines provided by ACROBiosystems have been validated on in vitro models of gastric organoid, intestinal organoid, colonic organoid, liver ductal organoid, brain organoids and blood vessel organoids, all of which can effectively maintain organoid growth with excellent performance.
Human EGF (Cat. No. EGF-H52H3), Noggin (Cat. No. NON-H5257), R-spondin1 (Cat. No. RS6-H4220), FGF10 (Cat. No. FG0-H5145) actively support gastric organoid growth during multiple passages and long-term culture processes.
Human EGF (Cat. No. EGF-H52H3), Noggin (Cat. No. NON-H5257), R-spondin1 (Cat. No. RS6-H4220) perfectly maintain intestinal organoid growth during multiple passages and long-term culture processes.
EGF (Cat. No. EGF-H52H3), Noggin (Cat. No. NON-H5257), R-spondin1 (Cat. No. RS6-H4220), maintain colonic organoid growth well during multiple passages and long-term culture processes.
Human EGF (Cat. No. EGF-H52H3), Noggin ( Cat. No. NON-H5257), R-spondin1 (Cat. No. RS6-H4220), developed by ACROBiosystems perfectly support multiple organoids growth. The cell viability measured by ATP is better than that of competitors.
The EGFR (Luc) HEK293 Reporter Cell was stimulated with serial dilutions of Human EGF Protein, His Tag, premium grade ( Cat. No. EGF-H52H3). The max induction fold was approximately 56 (Routinely tested).
Human R-Spondin 1 (21-146), His Tag, premium grade (Cat. No. RS6-H4220) induced TCF reporter activity in HEK293 cells. The EC50 for this effect is 0.0138-0.0163 µg/mL (Routinely tested).
Human FGF basic (Cat. No. BFF-H4117) stimulates proliferation of HUVEC in the range of 0-20 ng/mL. The EC50 for this effect is 0.416-0.630 ng/mL (Routinely tested).
The bio-activity of Human Activin A (Cat. No. ACA-H421b) was determined by dose-dependent inhibition of the proliferation of MPC-11 cells. The EC50 for this effect is typically ≤ 9.5 ng/mL (Routinely tested).
Human BMP-2, Tag Free(Cat. No. BM2-H4117) induces alkaline phosphatase production in ATDC5 cells. The EC50 for this effect is 1684-1736 ng/ml (Routinely tested).
The bio-activity of Human PDGF-BB Protein (Cat. No. PDB-H4112) was determined by dose-dependent stimulation of the proliferation of mouse 3T3 cells. The ED50 was 0.5-20 ng/mL (Routinely tested).