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Your Position: Home > EGF

EGF

Brief Information

Name:Epidermal growth factor
Target Synonym:Epidermal Growth Factor (Beta-Urogastrone),Beta-Urogastrone,Urogastrone,URG,EGF,HOMG4,Epidermal Growth Factor,Pro-Epidermal Growth Factor
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

EGF-H5117-Cell-based assay
 EGF CELL

Human EGF Protein, premium grade (Cat. No. EGF-H5117) stimulates EGFR (Luc) HEK293 Reporter Cell. The specific activity of Human EGF Protein, premium grade is>8.00 x 10^5 IU/mg, which is calibrated against human EGF WHO International Standard (NIBSC code: 91/530) (QC tested).

EGF-H52H3-Cell-based assay
 EGF CELL

Human EGF Protein, His Tag (Cat. No. EGF-H52H3) stimulates proliferation of EGFR (Luc) HEK293 Reporter Cell. The specific activity of Human EGF Protein, His Tag is > 3.00 X 10^5 IU/mg, which is calibrated against human growth factor EGF WHO International Standard (NIBSC code: 91/530) (QC tested).

EGF-M5265-SPR
 EGF SPR

Captured Mouse EGF R, His Tag (Cat. No. EGR-M5224) on CM5 Chip via anti-His antibody can bind Mouse EGF, Fc Tag (Cat. No. EGF-M5265) with an affinity constant of 5.44 nM as determined in SPR assay (Biacore T200 ) (Routinely tested).

EGF-H525b-SPR
 EGF SPR

Human EGF R, His Tag (Cat. No. EGR-H5222) captured on CM5 Chip via anti-His antibody can bind Human EGF, Mouse IgG2a Fc Tag (Cat. No. EGF-H525b) with an affinity constant of 2.63 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Synonym Name

EGF,URG,HOMG4

Background

Human epidermal growth factor (EGF) is also known as HOMG4 and  URG,and is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to its receptor EGFR. Epidermal growth factor can be found in human platelets, macrophages, urine, saliva, milk, and plasma. EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. All family members contain one or more repeats of the conserved amino acid sequence. The biological effects of salivary EGF include healing of oral and gastroesophageal ulcers, inhibition of gastric acid secretion, stimulation of DNA synthesis as well as mucosal protection from intraluminal injurious factors such as gastric acid, bile acids, pepsin, and trypsin and to physical, chemical and bacterial agents. Because of the increased risk of cancer by EGF, inhibiting it decreases cancer risk.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant anti-EGFR chimeric monoclonal antibody (Shanghai CP Guojian) CPGJ-602; 602; CPGJ602; CPGJ 602 Phase 2 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd Colorectal Neoplasms Details
EMD 55900 EMD-55900 Merck Serono Details

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