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Your Position: Home > IL-8

IL-8

Brief Information

Name:Interleukin-8
Target Synonym:IL8/NAP1 form VI,T-cell chemotactic factor,GCP/IL-8 protein III,IL8/NAP1 form II,GCP/IL-8 protein II,(Ala-IL-8)77,Emoctakin,IL8/NAP1 form IV,LYNAP,IL8/NAP1 form III,IL8/NAP1 form V,GCP/IL-8 protein I,Neutrophil-Activating Peptide 1,Interleukin 8,GCP-1,MDNCF,NAP-1,IL8,Beta Endothelial Cell-Derived Neutrophil Activating Peptide,Lung Giant Cell Carcinoma-Derived Chemotactic Protein,Lymphocyte Derived Neutrophil Activating Peptide,Alveolar Macrophage Chemotactic Factor I,Tumor Necrosis Factor-Induce
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Approved

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Part of Bioactivity data

IL8-H5258-ELISA
Human IL-8, Fc TagHuman IL-8, Fc Tag (Cat. No. IL8-H5258) ELISA bioactivity

Immobilized Human IL-8, Fc Tag (Cat. No. IL8-H5258) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human IL-8 Antibody, Human IgG1 with a linear range of 0.2-4 ng/mL (QC tested).

IL8-H82H3-ELISA
Biotinylated Human IL-8, His,AvitagBiotinylated Human IL-8, His,Avitag (Cat. No. IL8-H82H3) ELISA bioactivity

Immobilized Biotinylated Human IL-8, His,Avitag (Cat. No. IL8-H82H3) at 1 μg/mL (100 μL/well) on streptavidin precoated (0.5 μg/well) plate can bind Monoclonal Anti-Human IL-8 Antibody, Human IgG1 with a linear range of 0.06-2 ng/mL (QC tested).

Synonym Name

CXCL8,GCP1,IL8,LECT,LUCT,LYNAP,MDNCF,MONAP,NAF,NAP-1

Background

Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Mouse monoclonal antibody against human interleukin-8 cream Approved Dalian Asia Space Pharmaceutical Co Ltd, Dongguan Hongyuan Yishi Biotechnology Pharmaceutical Co Ltd 恩博克 Mainland China Eczema; Psoriasis Dalian Asia Space Pharmaceutical Co Ltd 2001-04-10 Psoriasis; Eczema Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AC-701 AC-701 Phase 2 Clinical Twi Pharmaceuticals Inc Rosacea; Exanthema Details
Cis-urocanic acid Cis-UCA; UCA-001; UCA-002 Phase 2 Clinical Herantis Pharma Dry Eye Syndromes; Urinary Bladder Neoplasms; Xerophthalmia; Dermatitis, Atopic Details
HL-2351 GX-P4; HL-2351; rhIL-1Ra-hyFc Phase 1 Clinical Genexine Inc Arthritis, Rheumatoid; Cryopyrin-Associated Periodic Syndromes Details
Ensereptide PXL-01 Phase 3 Clinical Promore Pharma Tissue Adhesions; Post-surgical adhesions; Cicatrix Details
HuMax-IL8 MDX-018; BMS-986253 Phase 2 Clinical Medarex, Genmab, Bristol-Myers Squibb Company Liver Neoplasms; Solid tumours; Carcinoma, Non-Small-Cell Lung Details

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