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Your Position: Home > IL-2 R alpha

IL-2 R alpha

Brief Information

Name:Interleukin-2 receptor alpha chain
Target Synonym:Insulin-Dependent Diabetes Mellitus 10,Interleukin-2 Receptor alpha Subunit,TAC antigen,p55,IL2-RA,Interleukin-2 receptor subunit alpha,IL-2-RA,IL-2R subunit alpha,IL2RA,Interleukin 2 Receptor Subunit Alpha,Interleukin 2 Receptor, Alpha,IL-2 Receptor Subunit Alpha,CD25 Antigen,IDDM10,IMD41,TCGFR,CD25,IL2R
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:14
Lastest Research Phase:Approved

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
CD25 mAb - 01 PCC Solid Tumor Solid tumor

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Cat. No. Species Product Description Structure Purity Feature
ILA-C52H8 Cynomolgus Cynomolgus IL-2 R alpha / CD25 Protein, His Tag (MALS verified)
ILA-C52H8-structure
ILA-C52H8-sds
ILA-H82F9 Human Biotinylated Human IL-2 R alpha / CD25 Protein, Fc,Avitag™ (MALS verified)
ILA-H82F9-structure
ILA-H82F9-sds
ILA-C52H4 Canine Canine IL-2 R alpha / CD25 Protein, His Tag
ILA-C52H4-structure
ILA-C52H4-sds
ILA-M52H9 Mouse Mouse IL-2 R alpha / CD25 Protein, His Tag
ILA-M52H9-structure
ILA-M52H9-sds
ILA-H82E6 Human Biotinylated Human IL-2 R alpha / CD25 Protein, His,Avitag™, premium grade
ILA-H82E6-structure
ILA-H82E6-sds
ILA-H52H9 Human Human IL-2 R alpha / CD25 Protein, His Tag
ILA-H52H9-structure
ILA-H52H9-sds
ILA-H5251 Human Human IL-2 R alpha / CD25 Protein, Fc Tag (MALS verified)
ILA-H5251-structure
ILA-H5251-sds
ACRO Quality

Part of Bioactivity data

ILA-H82E6-Cell-based assay
IL-2 R alpha CELL

Biotinylated Human IL-2 R alpha, His,Avitag, premium grade (Cat. No. ILA-H82E6) inhibits the IL-2-dependent proliferation of Mo7e cells. The EC50 for this effect is 0.57-0.81 µg/mL (Routinely tested).

Protocol
ILA-H52H9-Cell-based assay
IL-2 R alpha CELL

Human IL-2 R alpha, His Tag (Cat. No. ILA-H52H9) inhibits the IL-2 dependent proliferation of Mo7e cells. The EC50 for this effect is 0.35-0.77 µg/mL (Routinely tested).

Protocol
ILA-H52H9-SPR
IL-2 R alpha SPR

Human IL-2 R alpha, His Tag (Cat. No. ILA-H52H9) captured on CM5 chip via anti-His antibody, can bind Human IL-2, Tag Free with an affinity constant of 29.9 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
ILA-H5251-SPR
IL-2 R alpha SPR

Human IL-2 R alpha Protein, Fc Tag (Cat. No. ILA-H5251) captured on CM5 chip via anti-human IgG Fc antibody can bind Human IL-2, Tag Free with an affinity constant of 10.1 nM as determined in a SPR assay (Biacore T200) (Routinely tested)

Protocol

Customer Reviews

Synonym Name

IL2RA,CD25,p55,IL2-RA,IL-2-RA

Background

Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.

Clinical and Translational Updates

Related Molecule

IL-2

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Basiliximab CHT-25; chRFT5; CHI-621; SDZ-CHI-621 Approved Novartis Pharma Ag 舒莱, Simulect United States Rejection of organ transplantation Novartis Pharma Ag 1998-05-12 Anemia, Aplastic; Leukemia, Lymphocytic, Chronic, B-Cell; Kidney Failure, Chronic; Uveitis; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Emphysema; Pulmonary Disease, Chronic Obstructive; Colitis, Ulcerative; Primary Myelofibrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rejection of renal transplantation; Multiple Myeloma; Rejection of organ transplantation; Myelodysplastic Syndromes; Coronavirus Disease 2019 (COVID-19); Hodgkin Disease; Kidney Diseases; Keratoplasty rejection; Hemoglobinuria, Paroxysmal; Cytokine Release Syndrome; Leukemia, Myelogenous, Chronic Details
Daclizumab R-35; BIIB-019; RO-247375 Approved Abbvie Inc, Biogen Inc, F. Hoffmann-La Roche Ltd Zinbryta, Zenapax United States Rejection of organ transplantation F. Hoffmann-La Roche Ag 1997-12-10 Arthritis, Juvenile; Leukemia, T-Cell; Behcet Syndrome; Melanoma; Lymphoma; Iritis; Uveitis; Thrombocytopenia; Rejection in heart transplantation; Uveitis, Anterior; Colitis, Ulcerative; Asthma; Breast Neoplasms; Psoriasis; Multiple Sclerosis, Relapsing-Remitting; Retinal Diseases; Radiation Injuries; Carcinoma, Ductal; Rejection of organ transplantation; Multiple Sclerosis; HTLV-I Infections; Myelodysplastic Syndromes; Gastrointestinal Diseases; Inflammatory Bowel Diseases; Leukemia; Granulomatosis with Polyangiitis; HIV Infections; Diabetes Mellitus, Type 1 Details
Daclizumab biosimilar (Shanghai CP Guojian) Approved 健尼哌 Mainland China Rejection of renal transplantation null 2011-01-12 Rejection of renal transplantation Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Basiliximab biobetter (Mabtech/Sorrento) STI-003 Phase 3 Clinical Taizhou Maibo Taike Biotechnology Co Ltd Autoimmune Diseases Details
Anti-interleukin-2 receptor monoclonal antibody Mikbeta1 HuMikβ1-1 Phase 1 Clinical F. Hoffmann-La Roche Ltd, National Institutes Of Health Leukemia; Leukemia, Lymphoid; Celiac Disease; Paraparesis, Tropical Spastic; Leukemia, Large Granular Lymphocytic Details
LMB-2 LMB-2; LMB-2a Phase 2 Clinical National Cancer Institute Leukemia; Leukemia, Hairy Cell; Myeloproliferative Disorders; Myelodysplastic Syndromes; Skin Neoplasms; Leukemia-Lymphoma, Adult T-Cell; Lymphoma; Myelodysplastic-Myeloproliferative Diseases; Melanoma Details
MDNA-11 MDNA-11; MDNA11 Phase 2 Clinical Medicenna Therapeutics Corp Triple Negative Breast Neoplasms; Carcinoma, Hepatocellular; Melanoma; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Fallopian Tube Neoplasms; Endometrial Neoplasms; Peritoneal Neoplasms; Mesothelioma; Urinary Bladder Neoplasms; Solid tumours; Carcinoma, Ovarian Epithelial; Carcinoma, Merkel Cell; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Gastrointestinal Diseases; Carcinoma, Basal Cell; Esophageal Neoplasms; Stomach Neoplasms; Skin Melanoma Details
9MW-3911 9MW3911; 9MW-3911 Phase 1 Clinical Nanjing Nuo Aixin Biotechnology Co Ltd Neoplasms Details
Vopikitug RO-7296682; RG-6292 Phase 1 Clinical F. Hoffmann-La Roche Ltd Solid tumours; Neoplasms Details
BA-1106 TS-1904; BA-1106; RR-102 Phase 1 Clinical Shandong Boan Biotechnology Co Ltd Solid tumours; Neoplasms Details
90Y Basiliximab Phase 2 Clinical City Of Hope National Medical Center Lymphoma, T-Cell, Peripheral; Hodgkin Disease; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Lymphoma, T-Cell, Cutaneous; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell Details
PT-101 MK-6194; PT101; PT-101 Phase 2 Clinical Pandion Therapeutics Lupus Erythematosus, Systemic; Colitis, Ulcerative; Vitiligo; Dermatitis, Atopic Details
Inolimomab B-B10; BT-563; MAb-BT-563 Phase 3 Clinical Eusa Pharma, Jazz Pharmaceuticals Plc Graft vs Host Disease Details
XmAb-564 XmAb-564; XmAb-27564 Phase 1 Clinical Xencor Inc Autoimmune Diseases; Psoriasis; Dermatitis, Atopic Details
In 111-DOTA-Basiliximab Phase 1 Clinical City Of Hope National Medical Center Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute Details
Nemvaleukin alfa RDB-1450; RDB-1419; ALKS-4230 Phase 3 Clinical Alkermes Plc Solid tumours; Skin Melanoma; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Melanoma Details
Camidanlumab tesirine ADCT-301 Phase 2 Clinical Genmab A/S, Adc Therapeutics Sa Myeloproliferative Disorders; Carcinoma, Non-Small-Cell Lung; Melanoma; Leukemia, Myeloid, Acute; Fallopian Tube Neoplasms; Lymphoma, Non-Hodgkin; Colorectal Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Urinary Bladder Neoplasms; Myelodysplastic Syndromes; Solid tumours; Hodgkin Disease; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Ovarian Neoplasms Details
Humanized Anti-CD25 Antibody(Institute of Hematology & Blood Diseases Hospital) Details

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