Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Residue Detection kits
Residue Detection Assays
With biologics at the forefront of medical therapies, conditions that were previously considered untreatable are now being treated via therapeutic antibodies or cell and gene therapies, such as cancer. These therapies are sourced from biological origins, hence the term, “biologics”. As the biological products are seen as a new revolution of medicine, ensuring therapies are safe for patients across the world is critical due to the possibility of introduction of contamination, viruses, or other harmful contaminants during the manufacture process.
ACROBiosystems is now offering a series of kits for residue detection that follow both WHO and FDA industry guidances to robustly detect various impurities in your therapeutic antibody, cell therapies, vaccines, or any other biologics!
Feature products
resDNA Detection Kits
resDNA Detection Kits
Cat. No.Product Description
DNase / RNase Activity Detection Kits
DNase / RNase Activity Detection Kits
Cat. No.Product Description
ASE-A001RNase Activity Assay Kit (Fluorescence)
ASE-A002DNase Activity Assay Kit (Fluorescence)

Assay Data

Nuclease Detection Kits
Nuclease Detection Kits
Assay Data
  • resDNA Detection Kits

  • DNase / RNase Activity Detection Kits

  • Nuclease Detection Kits


High sensitivity and broad dynamic range using the E. coli resDNA Quantitative Kit (qPCR) (Cat. No. OPA-O002). (A) Typical analysis results obtained with Standard 1 (300 pg/μL) to 6 (3 fg/μL). (B) The standard curve of the 10-fold dilution series. PCR efficiency should be 90-110%.


Assay specificity. Standard curves generated using 10-fold serial dilution of E. coli genomic DNA (included in the kit).


Consistent quantitation across a broad range of fragment sizes. Standard curves were generated using a 10-fold serial dilution of gDNA and fragmented DNA. Fragmented DNA was generated by sonicating total E. coli genomic DNA (8min, 13min, 20min). Fragmentation of the DNA was confirmed by agarose gel analysis.


Add 90 μL of the working RNase Substrate solution to each 96-well plate, and add 10 μL of RNase A standards (0-200pg/mL*10μL / well = 0-2pg/well), incubate the plate in the fluorometer (BMG CLARIOstar) collecting real-time data at 1minute intervals for 30 minutes at 37°C using the settings described in this section. The RNase Activity Assay can be evaluated in rigorous kinetic terms using real-time data and the sensitivity can reach 0.03125pg.

Intra/Inter-Assay Statistics

Eight replicates of each of seven samples containing different concentrations of RNase were tested in one assay, the Intra-Assay and inter-Assay Precision CV are both<10%.
Intra-Assay Statistics

Intra-Assay Statistics


The probe is freeze-thawed 3 times, the kit performance meets the requirements, the sensitivity is not reduced, and the CV< 10%.

Interference effect

DNase Activity Assay Kit (Fluorescence) (Cat. No. ASE-A002) and RNase Activity Assay Kit (Fluorescence) (Cat. No. ASE-A001) were used to detect nuclease residues in the same sample. No significant cross-reactivity or interference was observed.

Typical Data

For each experiment, a standard curve needs to be set for each micro-plate, and the specific OD value may vary depending on different laboratories, testers, or equipments. The following example data is for reference only.

ACRO Quality

This web search service is supported by Google Inc.

Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
+1 888-377-6111
1 Innovation Way, Newark, DE 19711, USA

Leave a message