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Chemokine family proteins

Chemokine family proteins
Schematic diagram of IGF-targeted drugs

Chemokine network in the tumoral microenvironment immune response

Chemokines are small cytokines or signaling proteins secreted by cells. According to the number and arrangement of conserved L-Cysteine (C) at the N-terminal, chemokines can be classified into four classes: C, CC, CXC and CX3C. These chemokines signal through the seven-pass transmembrane chemokine receptor of G-protein coupling on the cell surface, which stimulate the cell directional migration. Homeostatic chemokines are constitutively expressed under physiological conditions and play a role in cell migration and homing, whereas inflammatory chemokines are rapidly secreted at sites of inflammation, thereby recruiting effector cells into inflamed tissues. Thus, chemokines play a central role in the development and homeostasis of the immune system and are involved in promoting the activation, differentiation, proliferation and apoptosis of immune cells and in all protective or destructive immune and inflammatory responses.

Furthermore, chemokine signaling and the chemotaxis of various cell populations also play a central role in the tumor microenvironment (TME). In the TME, many chemokines are released by immune cells, tumor cells and tumor-associated cells. These chemokines can change with time and space, attracting different types of tumor-promoting and anti-tumor immune cells. The migration of immune cells will further affect the progression and metastasis of tumors, and directly affect the immune response. Studies have revealed that chemokines have pleiotropic functions that affect anti-tumor immune responses and tumor progression. With this in mind, therapeutic strategies that utilize or target chemokines have been established over the past decade, leading to the testing of many new drug candidates in clinical trials. Notably, in chemokine-based therapies, chemokines are highly redundant in binding to receptors, the same receptor can bind to different chemokines, and vice versa. Therefore, only by simultaneously inhibiting chemokine and its receptor with the same physiological function can the therapeutic effect be healthier and lasts longer.

ACROBiosystems has developed a series of CC, CXC and CX3C subfamily chemokine proteins expressed by HEK293. The products are available in a variety of species and labels. In addition, based on the “FLAG” technology platform, we developed full-length chemokine receptor such as CCR5, CCR8, CXCR3, CXCR4, CXCR5, CXCR6, etc. which with high biological activity was verified by binding to antibody. Our recombinant chemokine family proteins can accelerate your scientific research and drug development programs.

Product Features

Various molecules, species, and tags

High purity verified by SDS-PAGE

High structural homogeneity verified by SEC-MALS and DLS

High activity verified by ELISA/SPR

Highly stable and convenient for storage and transportation

Product List
MoleculeCat. No.SpeciesProduct DescriptionPreorder/Order
CCL1CC1-H82E9HumanBiotinylated Human CCL1 / I-309 / C-C motif chemokine 1 Protein, His,Avitag™ (MALS verified)
CC1-H5254HumanHuman CCL1 / I-309 Protein, Fc Tag (MALS verified)
CCL2CC2-H5255HumanHuman CCL2 / MCP-1 Protein, Fc Tag (MALS verified)
CCL3CC3-H5249HumanHuman CCL3 / MIP-1 alpha Protein, His Tag
CCL5CC5-H5251HumanHuman CCL5/RANTES Protein, Fc Tag (MALS verified)
CCL7CC7-H52H6HumanHuman CCL7 / MCP-3 Protein, His Tag
CCL14CC4-H5249HumanHuman CCL14 / HCC-1 Protein, His Tag
CCL17CC7-H5256HumanHuman CCL17 / TARC Protein, Fc Tag (MALS verified)
CCL22CC2-H5257HumanHuman CCL22 / MDC Protein, Fc Tag
CCL24CC4-H52H1HumanHuman CCL24/Eotaxin-2 Protein, His Tag
CXCL1CX1-H5253HumanHuman CXCL1 Protein, Fc Tag
CXCL4CX4-H52H9HumanHuman CXCL4 / PF4 Protein, His Tag
CXCL10CX0-H51H1HumanHuman CXCL10 / IP-10 Protein, His Tag
CXCL13CX3-H1249HumanHuman CXCL13 / BCA-1 Protein, His Tag
CXCL16CX6-H5254HumanHuman CXCL16 Protein, Fc Tag
CX3CL1CX1-H5221HumanHuman CX3CL1 / Fractalkine Protein, His Tag
CX1-H8221HumanBiotinylated Human CX3CL1 Protein, His Tag, ultra sensitivity (primary amine labeling)
CX1-C5222CynomolgusCynomolgus CX3CL1 / Fractalkine Protein, His Tag
CXCR3CX3-H52P4HumanHuman CXCR3 Full Length Protein-VLP
CX3-H52D5HumanHuman CXCR3 Protein, Flag,His Tag (Detergent)
CX3-M52P7MouseMouse CXCR3 Full Length Protein (VLP)
CXCR4CX4-H5219HumanHuman CXCR4 / CD184 Full Length Protein-VLP
CX4-H5269HumanHuman CXCR4 / CD184 Protein, Fc Tag
CXCR5CX5-H52P4HumanHuman CXCR5 Full Length Protein-VLP
CX5-H52D6HumanHuman CXCR5 Protein, Flag,His Tag (Detergent)
CXCR6CX6-H52P3HumanHuman CXCR6 / CD186 Full Length Protein (VLP)
CCR4CC4-H52P3HumanHuman CCR4 Full Length Protein (VLP)
CCR5CC5-H52P3HumanHuman CCR5 Full Length Protein-VLP
CC5-H52P5HumanFluorescent Human CCR5 Full Length Protein (VLP)
CC5-H52D1HumanHuman CCR5 Protein, Flag,His Tag (Detergent)
CCR6CC6-H52P3HumanHuman CCR6 Full Length Protein (VLP)
CCR7CC7-H52P3HumanHuman CCR7 Full Length Protein (VLP)
CCR8CC8-H52P4HumanHuman CCR8 Full Length Protein-VLP
Verification Data
High purity and structural homogeneity verified by SDS-PAGE, SEC-MALS and DLS

The purity of Human CCL5, Fc Tag (Cat. No. CC5-H5251) is more than 85% and the molecular weight of this protein is around 71-96 kDa verified by SEC-MALS.


The mean peak Radius of VLP (Cat. No. CX3-H52P4) is 60-80 nm with more than 95% intensity as determined by dynamic light scattering (DLS).

High biological activity verified by ELISA


Immobilized Biotinylated Human CCL1, His,Avitag (Cat. No. CC1-H82E9) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Human CCR8, Flag,His Tag with a linear range of 0.3-39 ng/mL (QC tested).


Immobilized Human CXCR5 Full Length Protein-VLP (Cat. No. CX5-H52P4) at 5 μg/mL (100 μL/well) can bind Monoclonal Anti-Human CXCR5 antibody, Human IgG4 | Human Kappa with a linear range of 1-78 ng/mL (QC tested).

High affinity verified by SPR


Anti-CXCR3 antibody immobilized on CM5 Chip can bind Human CXCR3 Full Length Protein-VLP (Cat. No. CX3-H52P4) with an affinity constant of 60.9 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).


Human CCR5, Flag,His Tag (Cat. No. CC5-H52D1) captured on CM5 chip via anti-His antibody can bind Anti-CCR5 antibody (Human IgG1) with an affinity constant of 0.0737 nM as determined in a SPR assay (in presence of DDM and CHS) (Biacore T200).

  • 1. Kohli K, Pillarisetty V G, Kim T S. Key chemokines direct migration of immune cells in solid tumors[J]. Cancer gene therapy, 2022, 29(1): 10-21.

  • 2. Bule P, Aguiar S I, Aires-Da-Silva F, et al. Chemokine-directed tumor microenvironment modulation in cancer immunotherapy[J]. International Journal of Molecular Sciences, 2021, 22(18): 9804.

  • 3. Hughes C E, Nibbs R J B. A guide to chemokines and their receptors[J]. The FEBS journal, 2018, 285(16): 2944-2971.

  • 4. Chow M T, Luster A D. Chemokines in cancer[J]. Cancer immunology research, 2014, 2(12): 1125-1131.

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