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Fig. FACS analysis of SIRPα/β on HEK293/Human SIRP alpha Stable Cell Line.
FACS assay shows that Anti-SIRPα/β antibody can bind to HEK293/Human SIRP alpha Stable Cell Line. HEK293/Human SIRP alpha Stable Cell Line was red line, Negative control HEK293 cells was grey line (QC tested).
5e5 of overexpressing mouse CD47 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Mouse SIRP alpha, His Tag (Cat. No. SIA-MP2H6) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).
Loaded Human CD47, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. CD7-H52A5) on Protein A Biosensor, can bind Human SIRP alpha, His Tag (Cat. No. SIA-H5225) with an affinity constant of 1.1 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).
Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
---|---|---|---|---|---|---|---|---|---|---|
Elagolix/estradiol/norethindrone acetate | Approved | Abbvie Inc | Oriahnn | United States | Menorrhagia | Abbvie Inc | 2020-05-29 | Menorrhagia | Details | |
Relugolix/Estradiol/Norethindrone Acetate | Approved | Myovant Sciences | MYFEMBREE | United States | Pain; Endometriosis | Myovant Sciences | 2021-05-26 | Pain; Endometriosis; Leiomyoma; Uterine Neoplasms; Menorrhagia | Details |
Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
---|---|---|---|---|---|
GS-0189 | FSI-189; GS-0189; FSI89 | Gilead Sciences Inc | Details | ||
BR-105 | BR105 | Phase 1 Clinical | Hisun Biopharmaceutical Co Ltd, BioRay Pharmaceutical Co Ltd | Neoplasms | Details |
TQB-2928 | TQB-2928 | Phase 1 Clinical | Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd | Hematologic Neoplasms; Solid tumours; Neoplasms | Details |
[89Zr]Zr- BI-765063(Boehringer Ingelheim) | Phase 1 Clinical | Boehringer Ingelheim Corp | Squamous Cell Carcinoma of Head and Neck; Melanoma; Carcinoma, Non-Small-Cell Lung | Details | |
AL-008 | AL-008; IBI-397 | Phase 1 Clinical | Alector | Neoplasms | Details |
ELA-026 | ELA-026 | Phase 1 Clinical | Electra Therapeutics Inc | Lymphohistiocytosis, Hemophagocytic | Details |
BI-765063 | OSE-172; BI-765063 | Phase 1 Clinical | Ose Immunotherapeutics | Solid tumours; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma | Details |
Anzurstobart | CC-95251; BMS-986351 | Phase 1 Clinical | Celgene Corp | Myelodysplastic Syndromes; Leukemia, Myeloid, Acute | Details |
RRx-001 | ABDNAZ; RRx-001 | Phase 3 Clinical | Epicentre Biotechnologies Llc | Cholangiocarcinoma; Stomatitis; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Brain metastases; Carcinoma, Small Cell; Lymphoma; Colorectal Neoplasms; Brain Neoplasms; Solid tumours; Central Nervous System Neoplasms; Neuroendocrine Tumors; Oligodendroglioma; Neoplasms; Carcinoma, Ovarian Epithelial; Glioblastoma; Small Cell Lung Carcinoma | Details |
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