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Brief Information

Name:CD276 antigen
Target Synonym:B7 homolog 3,PSEC0249,UNQ309/PRO352,B7-H3,CD276 antigen,B7H3,CD276,CD276 Molecule,Costimulatory Molecule,4Ig-B7-H3,B7RP-2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:35
Lastest Research Phase:NDA/BLA


Project Name Modality Therapeutic Area Indications Stage Right Available
B7H3×PD-L1 bsAb Bispecific antibody Oncology/Cancer Advanced solid tumor Preclinical Global
Anti-B7H3 ADC Bioconjugates Oncology/Cancer Broad cancer PCC Global
B7-H3×CD3 BsAb for solid tumor Monospecific antibody Oncology/Cancer Solid Tumor IND Global

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Part of Bioactivity data

B73-H52E2-Cell-based assay

Human B7-H3, His Tag (Cat. No. B73-H52E2) inhibits Anti-CD3-induced proliferation of PBMC. The EC50 for this effect is 2.24-3.36 μg/mL (Routinely tested).


Immobilized Monoclonal Anti-Human B7-H3 / B7-H3 (4Ig) Antibody, Human IgG1 at 2 μg/mL (100 μL/well) can bind Biotinylated Human B7-H3 Protein, Avitag,His Tag (Cat. No. B73-H82E6) with a linear range of 5-39 ng/mL (QC tested).

B7-H3 MALS images

The purity of Biotinylated Human B7-H3 Protein, Fc,Avitag (Cat. No. B73-H82F5) is more than 90% and the molecular weight of this protein is around 115-135 kDa verified by SEC-MALS.

Synonym Name

B7-H3,CD276,B7 homolog 3


B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Fully Human B7H3 CAR-T Cells Therapy fhB7H3.CAR-Ts Phase 2 Clinical The Affiliated Hospital Of Xuzhou Medical University Ovarian Neoplasms; Carcinoma, Hepatocellular Details
IBB-0979 IBB0979; IBB-0979 Phase 2 Clinical SunHo (China) BioPharmaceutical Co Ltd Solid tumours; Neoplasms; Neoplasm Metastasis Details
BAT-8009 BAT8009; BAT-8009 Phase 1 Clinical Bio-Thera Solutions Ltd Solid tumours Details
CC-3 CC-3 Phase 1 Clinical Eberhard Karls University Of Tubingen, Germany Colorectal Neoplasms; Gastrointestinal Neoplasms Details
TX103 CAR-T cell therapy(Fuzhou Tuoxin Tiancheng Biotechnology) Phase 1 Clinical Fuzhou Tuoxin Tiancheng Biotechnology Co Ltd Solid tumours; Glioma Details
KT-095 KT-095 Phase 1 Clinical Nanjing Kati Medical Technology Co Ltd Solid tumours Details
124I-omburtamab 124I-8H9; 124I-8H9-(B7-H3) Phase 1 Clinical Memorial Sloan Kettering Cancer Center, Y-Mabs Therapeutics Inc Brain Neoplasms; Glioma Details
IBI334 IBI334; IBI-334 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours; Neoplasms Details
Allogenic B7H3-targeting CAR-γδT Cell Therapy QH104 Cell; QH-104 Cell Phase 2 Clinical Suzhou Dushu Lake Hospital (Dushu Lake Hospital Affiliated To Soochow University) Glioblastoma Details
SCRI-CARB7H3 SCRI-CARB7H3 Phase 1 Clinical Seattle Children'S Hospital Neuroblastoma; Choroid Plexus Neoplasms; Neoplasms, Germ Cell and Embryonal; Melanoma; Glioma; Diffuse Intrinsic Pontine Glioma; Neuroectodermal Tumors, Primitive; Sarcoma; Sarcoma, Clear Cell; Neurofibrosarcoma; Sarcoma, Ewing; Osteosarcoma; Retinoblastoma; Teratoma; Sarcoma, Synovial; Central Nervous System Neoplasms; Wilms Tumor; Diffuse midline glioma; Hepatoblastoma; Rhabdoid Tumor; Desmoplastic Small Round Cell Tumor; Carcinoma; Rhabdomyosarcoma; Medulloblastoma; Solid tumours; Ependymoma Details
YL-201 YL-201; YL201 Phase 2 Clinical MediLink Therapeutics Co Ltd Solid tumours Details
EX-105 EX-105; EX105 Phase 1 Clinical Guangzhou Excelmab Inc Solid tumours Details
Autologous CAR-T Cells Targeting B7-H3(Unc Lineberger Comprehensive Cancer Center) Phase 1 Clinical Unc Lineberger Comprehensive Cancer Center Neoplasms; Pancreatic Neoplasms Details
7MW3711 7-MW-3711; 7MW3711 Phase 2 Clinical Mabwell (Shanghai) Bioscience Co Ltd Solid tumours; Neoplasms Details
IBI129 IBI-129; IBI129 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours Details
4SCAR-276 4SCAR-276 Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Solid tumours Details
CD-276-targeted Chimeric Antigen Receptor T Cell Therapy CD276 CAR-T Phase 2 Clinical Shenzhen University General Hospital Pancreatic Neoplasms Details
B7-H3-targeting CAR-T cell therapy Beijing Tiantan Hospital, Capital Medical University Details
Enoblituzumab MGA-271; TJ271 Phase 2 Clinical Macrogenics Inc Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Peritoneal Neoplasms; Osteosarcoma; Neuroblastoma; Sarcoma, Ewing; Prostatic Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Ovarian Neoplasms; Wilms Tumor; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Carcinoma, Renal Cell; Desmoplastic Small Round Cell Tumor; Abdominal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Solid tumours; Rhabdomyosarcoma; Head and Neck Neoplasms Details
MT-027 MT-027 Phase 1 Clinical T-Maximum Pharmaceutical (Suzhou) Co Ltd Glioma Details
TAA-06 TAA06-UCAR-γδT; TAA-06 Phase 1 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd Solid tumours; Neuroblastoma; Colorectal Neoplasms; Lung Neoplasms; Melanoma Details
Mirzotamab clezutoclax ABBV-155 Phase 1 Clinical Abbvie Inc Solid tumours Details
XmAb-808 XmAb808 Phase 1 Clinical Xencor Inc Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details
EGFR/B7H3 CAR-T EGFR/B7H3 CAR-T Phase 1 Clinical Second Affiliated Hospital Of Guangzhou Medical University Triple Negative Breast Neoplasms; Lung Neoplasms Details
B7-H3 CAR T-cell therapy(Stanford University) B7-H3CART Phase 1 Clinical Stanford University Nervous System Diseases Details
DB-1311 DB-1311 Phase 2 Clinical Duality Biologics Co Ltd Solid tumours; Neoplasm Metastasis Details
Vobramitamab duocarmazine MGC-018 Phase 2 Clinical Macrogenics Inc Liver Neoplasms; Solid tumours; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms; Carcinoma, Pancreatic Ductal; Melanoma Details
TAK-280 MVC-280; TAK-280 Phase 2 Clinical Maverick Therapeutics Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details
Obrindatamab MGD-009; B7-H3 x CD3 Phase 2 Clinical Macrogenics Inc Mesothelioma; Carcinoma, Non-Small-Cell Lung; Melanoma; Thyroid Neoplasms; Sarcoma; Neuroblastoma; Neurofibrosarcoma; Prostatic Neoplasms; Breast Neoplasms; Ovarian Neoplasms; Sarcoma, Synovial; Urinary Bladder Neoplasms; Wilms Tumor; Pancreatic Neoplasms; Colonic Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Rhabdomyosarcoma Details
UTAA06 UTAA-06 Phase 1 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd Leukemia, Myeloid, Acute Details
HS-20093 HS20093; HS-20093 Phase 2 Clinical Shanghai Hansoh Biomedical Co Ltd Solid tumours; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Small Cell Lung Carcinoma; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Osteosarcoma Details
B7-H3 CAR-T cell therapy (Boyuan Runsheng Pharma) Phase 2 Clinical Boyuan Runsheng Pharma (Hangzhou) Co Ltd Solid tumours; Glioblastoma Details
MHB088C MHB-088C Phase 2 Clinical Minghui Pharmaceutical Pty Ltd Solid tumours Details
Anti-CD276 CAR T-cell therapy (Persongen ) Phase 1 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd Stomach Neoplasms; Osteosarcoma; Neuroblastoma; Lung Neoplasms Details
Ifinatamab deruxtecan DS-7300; DS-7300a; MABX-9001a Phase 2 Clinical Daiichi Sankyo Co Ltd Solid tumours; Small Cell Lung Carcinoma Details

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