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Flow Cytometry assay shows that Human B7-1, Mouse IgG2a Fc Tag (Cat. No. B71-H52A4) can bind to 293 cell overexpressing human CTLA-4. The concentration of Human B7-1 is 1 μg/mL (Routinely tested).
FACS analysis shows that the binding of Human B7-1, Mouse IgG2a Fc Tag (Cat. No. B71-H52A4) to 293 overexpressing CTLA-4 was inhibited by increasing concentration of neutralizing Anti-human CTLA-4 antibody. The concentration of Human B7-1 is 1 μg /mL. The IC50 is 5.5 μg/mL (Routinely tested).
Immobilized Human / Cynomolgus / Rhesus macaque CD28, Fc Tag (Cat. No. CD8-H525a) on CM5 Chip can bind Human B7-1, Mouse IgG2a Fc Tag (Cat. No. B71-H52A4) with an affinity constant of 2.72 μM as determined in a SPR assay (Biacore T200) (Routinely tested).
Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
---|---|---|---|---|---|---|---|---|---|---|
Belatacept | LEA29Y; LEA-029; BMS-224818; L104EA29YIg | Approved | Bristol-Myers Squibb Company | Nulojix | EU | Rejection of renal transplantation | Bristol-Myers Squibb Pharma Eeig | 2011-06-15 | Rejection of renal transplantation; Diabetes Mellitus, Type 1; Arthritis, Rheumatoid; Pancreatic neuroendocrine tumors (pNET); Proteinuria; Rejection of organ transplantation; Delayed Graft Function; Rejection in heart transplantation; Kidney Failure, Chronic | Details |
Abatacept | ONO-4164; BMS-188667; BMS-188667SC; ONO-4164SC | Approved | Bristol-Myers Squibb Company | Orencia | United States | Graft vs Host Disease | Bristol Myers Squibb Srlcompany | 2005-12-23 | Arthritis, Psoriatic; Arthritis; Arthralgia; Common Variable Immunodeficiency; Cardiovascular Diseases; Sjogren-Larsson Syndrome; Urticaria; Asthma; Colitis, Ulcerative; Nephrotic Syndrome; Lupus Erythematosus, Systemic; Takayasu Arteritis; Psoriasis; Anemia, Aplastic; Glomerulosclerosis, Focal Segmental; Mucopolysaccharidosis I; Polymyalgia Rheumatica; Multiple Sclerosis; Leukocyte-Adhesion Deficiency Syndrome; Uveitis; Granulomatous Disease, Chronic; Lymphohistiocytosis, Hemophagocytic; Scleroderma, Diffuse; Inflammation; Myocarditis; Eye Diseases; Muscular Diseases; Crohn Disease; Behcet Syndrome; Kostmann Syndrome; Anemia, Sickle Cell; Thrombasthenia; Vitiligo; Spondylitis, Ankylosing; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Myasthenia Gravis; Granulomatosis with Polyangiitis; Wiskott-Aldrich Syndrome; Polymyositis; Diabetes Mellitus, Type 1; Multiple Sclerosis, Relapsing-Remitting; Hematologic Diseases; Alopecia Areata; Giant Cell Arteritis; Myositis; Dermatomyositis; Immunoglobulin G | Details |
Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
---|---|---|---|---|---|
Membrane bound ligand T-SIGn virus | NG-348 | Phase 1 Clinical | Psioxus Therapeutics Ltd | Neoplasms | Details |
rVV-740CTA vaccine (University Hospital Basel) | rVV-740CTA | University Hospital Basel | Details | ||
CTLA-4/FasL fusion protein (KAHR Medical) | KAHR-102 | Kahr Medical | Details | ||
Belatacept biosimilar (Alphamab) | KN-019 | Phase 2 Clinical | Rejection of renal transplantation; Arthritis, Rheumatoid | Details | |
Chimeric antigen receptor T-cell therapy (Hunan Zhaotai Yongren Biotech) | Z-CTLs | Phase 1 Clinical | Hunan Zhaotai Yongren Biotech Co Ltd | Carcinoma, Non-Small-Cell Lung | Details |
Recombinant human CTLA-4-FC fusion protein(Beijing Vdjbio) | Phase 1 Clinical | Beijing Vdjbio Co Ltd | Arthritis, Rheumatoid | Details | |
ORCA-010 | ORCA-010 | Phase 2 Clinical | Orca Therapeutics Bv | Prostatic Neoplasms | Details |
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