Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
user
  1. Dashboard
  2. My Profile
  3. My Address
  4. My Orders
  5. Acro Membership
Login Register
Promotion
Recombinant Proteins ClearClear history
Recombinant Proteins CloseClose
Browse Products By Molecule Name a-zA-Z
TL1A Hot |GMP Cytokines Hot |FcRn Binding Kit (TR-FRET) New |Claudin 18.2
0
There is no goods in the shopping cart !
My Cart|Secure Checkout
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Mucin-1

Mucin-1

Brief Information

Name:Mucin-1
Target Synonym:PEM,Medullary Cystic Kidney Disease 1 (Autosomal Dominant),Tumor Associated Epithelial Mucin,CD227 Antigen,H23 Antigen,MUC-1/SEC,ADMCKD1,Cancer antigen 15-3,Tumor-associated mucin,MUC1-alpha,MUC1-beta,MUC-1/X,MUC1/ZD,Mucin-1,ADMCKD,MCKD1,MAM6,MCKD,MCD,Polymorphic epithelial mucin,PUM,MUC1-NT,Episialin,CD227,MUC1-CT,MUC1,Mucin 1, Cell Surface Associated,Tumor-Associated Epithelial Membrane Antigen,Peanut-Reactive Urinary Mucin,Carcinoma-Associated Mucin,Krebs Von Den Lungen-6,CA 15-3,H23AG,MUC-1,
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:21
Lastest Research Phase:Phase 2 Clinical

Product Inquiry

* We couldn't find what you're looking for. You can let us help by filling the form below. Our tech team will get back to you shortly.
* This form is only used to collect product demand consultation. All the information will be kept strictly confidential.
Product inquiry collection form
*
*
*
*
*
*
*
*
*
ACRO Quality

Part of Bioactivity data

MU1-HA2H8-Cell-based assay
Mucin-1 FACS

5e5 of anti-Mucin-1 (F1C) CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human Mucin-1 Protein, His Tag (Cat. No. MU1-HA2H8) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).

Protocol
MU1-H82E5-Cell-based assay
Mucin-1 FACS

2e5 of Anti-Mucin-1 CAR-293 cells were stained with 100 μL of 0.1 μg/mL of Biotinylated Human Mucin-1, His,Avitag (Cat. No. MU1-H82E5) and negative control protein respectively, washed and then followed by PE-SA and analyzed with FACS (Routinely tested).

Protocol
MU1-M52H4-SPR
Mucin-1 SPR

Mouse Mucin-1 (21-535) Protein, His Tag (Cat. No. MU1-M52H4) immobilized on CM5 Chip can bind anti-mMUC1-mAb with an affinity constant of 302 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
MU1-H5254-ELISA
Mucin-1 ELISA

Immobilized Human Mucin-1 (24-380), Fc Tag (Cat. No. MU1-H5254) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Mucin-1 Antibody, Mouse IgG1 (SM-3) with a linear range of 0.5-4 ng/mL (QC tested).

Protocol

Synonym Name

Mucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1,SEC,MUC-1,X,MUC1,ZD,PEM,PEMT,PUM,CA15-3,Episialin

Background

Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Anti-MUC1 CAR T cell (Guangzhou Anjie Biomedical) Phase 2 Clinical Guangzhou Anjie Biomedical Technology Esophageal Neoplasms; Prostatic Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Recombinant HSP-MUC1 fusion protein (Newsummit) Phase 1 Clinical Shanghai Xinshengyuan Biological Medicine Co Ltd Breast Neoplasms Details
Anti-MUC1 CAR T-cell therapy (Guangzhou Anjie Biomedical Technology/University of Technology Sydney) Phase 2 Clinical The First Affiliated Hospital Of Guangdong Pharmaceutical University, Guangzhou Anjie Biomedical Technology, University of Sydney Carcinoma, Non-Small-Cell Lung Details
Anti MUC 1 chimeric antigen receptor T cell therapy (Innovative Cellular) Phase 1 Clinical Innovative Cellular Therapeutics Co Ltd Pancreatic Neoplasms; Breast Neoplasms; Lung Neoplasms Details
ICTCAR-046 ICTCAR-046 Clinical Innovative Cellular Therapeutics Co Ltd Pancreatic Neoplasms Details
BromAc Mucpharm Pty Ltd Details
Cantuzumab ravtansine Immunogen Inc Details
Anti-MUC1 CAR-T cell therapy (PersonGen) Persongen Biotherapeutics (Suzhou) Co Ltd Details
huMNC2-CAR44 huMNC2-CAR44 Minerva Biotechnologies Details
CART-TnMUC1 Phase 1 Clinical University Of Minnesota, University Of Pennsylvania Ovarian Neoplasms; Triple Negative Breast Neoplasms; Multiple Myeloma; Carcinoma, Pancreatic Ductal; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung Details
DXC-005 DXC-005 Phase 1 Clinical Hangzhou Dac Biotech Company Ltd Solid tumours Details
P-MUC1C-ALLO1 P-MUC1C-ALLO1; P-MUC1C-101 Phase 1 Clinical Poseida Therapeutics Inc Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Pancreatic Neoplasms; Nasopharyngeal Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Anti-MUC1 monoclonal antibody (OncoQuest) AR20.5; mAb-AR20.5; Anti-MUC1 AR20.5 Phase 2 Clinical Altarex Pancreatic Neoplasms Details
GO-2032c GO-203-2C Phase 2 Clinical Genus Oncology Llc, Dana-Farber Cancer Institute Solid tumours; Multiple Myeloma; Leukemia, Myeloid, Acute Details
M-1231 M-1231 Phase 1 Clinical Emd Serono Research & Development Institute Inc, Merck Serono Solid tumours; Esophageal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
MUC1-Poly-ICLC MUC1-poly-ICLC Phase 2 Clinical University Of Pittsburgh Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Adenoviral MUC1 vaccine (Etubics) ETBX-061; Ad5-MUC1 Phase 2 Clinical Etubics Corp, Immunitybio Inc, Nantkwest Inc Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Lymphoma, Non-Hodgkin; Lung Neoplasms; Colorectal Neoplasms; Prostatic Neoplasms; Ovarian Neoplasms; Chordoma; Carcinoma, Transitional Cell; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Neoplasms; Colonic Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Merkel Cell Details
Cancer vaccine (BN ImmunoTherapeutics/National Cancer Institute) CVAC-301; CV-301 Phase 2 Clinical Therion Biologics Solid tumours; Ovarian Neoplasms; Intestinal Neoplasms; Cystadenocarcinoma; Pancreatic Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Melanoma; Adenocarcinoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
MUC1-peptide-DC-CTL (Beijing Doing Biomedical) Phase 1 Clinical Stomach Neoplasms Details
MUC1-gene-DC-CTL (Beijing Doing Biomedical) Phase 1 Clinical Stomach Neoplasms Details

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Email
Email
order@acrobiosystems.com
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA
linkedin twitter facebook youtube

Leave a message

Copyright © 2017 ACROBiosystems. All Rights Reserved
|Related Links|Privacy Policy|Terms and Conditions|Legal|Sitemap