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1. Binds to human CD47 on a novel epitope.
2. Better neutralization ability and anti-tumor efficacy than Hu5F9.
3. Shows great potential in combination with anti-PD-1 therapies .
4. Low erythrocyte binding and cause no hemagglutination in vitro.
5. In acute and chronic GLP toxicity studies in cynomolgus monkeys, DS003 did not cause anaemia or thrombopenia.
1. Asset type: Humanized recombinant CD47 Monoclonal Antibody
2. Indication: Hematologic tumors, solid tumors
3. Research phase: IND approval is expected
4. Cooperation demands: License-out or co-development
5. Research progress：
1) Erythrocyte binding and hemagglutination assay was completed. The asset showed low erythrocyte binding and did not cause hemagglutination of human erythrocytes in vitro.
2) Monkey single/ multiple dose toxicity studies were completed. The asset did not cause anaemia or thrombopenia.
3) The stable cell line of the asset has been established in CHO host cells with commercial license.
4) IND approval is expected in the 3rd quarter of 2022.
Explore our catalog of therapeutic antibody solutions to find the right products for you! We are dedicated to delivering solutions designed to help you drive innovation and push the boundaries of what therapeutic antibodies can be.
Organoid Toolbox is a collection of organoid solutions including ready-to-use organoids, organoid differentiation kits, and a variety of services to accelerate the progress of your drug development project.
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50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process.
GMP grade cytokines, reagents for cell activation, gene edition, DNA/RNA removal, etc. Particularly focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey.
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Aneuro provides innovative solutions for neuroscience research. Recombinant proteins, neural factors, pre-formed fibrils, electrophysiological electrodes, as well as Organoid Toolbox all in Aneuro aiming to advance neuroscience research, develop therapeutic interventions, and improve diagnostic methods for neurological diseases.
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