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Your Position: Home > Discovery Solutions for Cell and Gene Therapy

Discovery Solutions for Cell and Gene Therapy

Discovery Solutions for Cell and Gene Therapy
Background
CGT solutions
PRODUCT LIST
Background
The pipeline of advanced therapy is expanding at a rate never seen before, with a number of cell and gene therapies (CGT) now reaching the market. Continuing advances in CGT are transforming how biopharma companies treat and potentially cure certain diseases.
Cell and gene therapies are the next wave of therapeutic innovation in the life sciences industry. However, the consequent challenges in development, manufacture, quality control, supply chain and commercial affect the whole industry.
As a leading manufacturer of recombinant proteins and other critical reagents to support the development of biomedicine, ACROBiosystems is proud to stand by you in the CGT journey. We employ an application-oriented development strategy, with a particular focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process.
CGT solutions

Early drug discovery

CAR-T targets
Suitable for immunization, antibody screening and antibody affinity testing
More than 50 targets for solid tumor and blood tumor
Alexa Fluor/APC/PE/FITC/Biotin/Unconjugated labeled proteins are available
Some products have completed the FDA DMF filing (DMF No.: 034936), which can support your IND, NDA, and BLA.
>>>Find out more

TCR-T targets
Suitable for TCR testing and screening
Monomer and tetramer are available for different applications
High purity verified by SDS-PAGE; High affinity verified by SPR
High stability and batch-to-batch consistency
>>>Find out more
CRISPR-Cas Nuclease
Suitable for structure design and gene edition
High enzyme activity: improve the cutting efficiency to 90% and make it easier to edit gene by CRISPR
High purity verified by SDS-PAGE(＞90%）and SEC-MALS(＞95%）
Bioactivity verified by in-vivo/ in-vitro assay: gene knockout activity in vivo and fragment cleavage activity in vitro
Low endotoxin less than 0.1 EU/ug
High stability and batch-to-batch consistency
RUO grade products can save the cost in early study; GMP grade products are coming
>>>Find out more

Manufacture/Quality control

GMP Grade Cytokines
Suitable for cell culture and expansion
（research use and ex vivo cell culture processing only, and is not intended for human in vivo applications）
Strict Quality Control Standards: 16 quality control standards and Excellent safety profile. High stability and batch-to-batch consistency.
GMP Grade Quality Management System: ISO 5 cleanrooms used for filling, raw materials and packing materials are registered, and facilities are available for online and on-site audits.
Accelerating Global Regulatory Approval of Biological Products: A comprehensive set of regulatory documents and validation reports are available by request. FDA DMF filing in progress.
>>>Find out more

GENIUSTMNuclease
Suitable for nucleic acid removing in Lentivirus purification process and AAV preparation process
High purity verified by SDS-PAGE and HPLC(> 95%), high specific activity > 1.0 x 106 unit/mg
Tag Free and close to the natural state, performs a high enzyme activity≥250 U/μl
No protease activity, high specificity and sensitivity
Broader reaction conditions: Optimum temperature 35 °C -42 °C, optimum pH 8.0 - 8.5
Some products have completed the FDA DMF filing (DMF No.: 034936), which can support your IND, NDA, and BLA.
RUO grade products can save the cost in early study; GMP grade products are coming
>>>Find out more

Human T cell Activation/Expansion CD3/CD28 Beads, premium grade DMF Filed
Recommended for human T cell activation & expansion
Microbial testing and ultra-low endotoxin （＜2 EU/mg）
Efficient activation and expansion
High batch-to-batch consistency
Highly stable and convenient for storage and transportation in lyophilization
Premium grade seamlessly transition from preclinical to clinical research ;GMP grade products are coming
>>>Find out more

GMP Monoclonal Anti-Human CD3 Antibody(OKT3)
Recommended for human T cell activation & expansion
High purity: SDS-PAGE>95%
Endotoxin level: <0.002 EU / μg
Host cell protein: <0.02 ng/μg
Animal-origin free materials
Lot-to-lot consistency
>>>Find out more

Star Staining New Generation Fluorescent-labeled Products
One-step solution for CAR detection with higher specificity and less processing time, no secondary antibody and non-specific background
More fluoresces are available: Alexa Fluor/FITC/PE/APC, etc.
More advanced technology: use new-generation site-specific labeling technology to maintain natural conformation and modification of the proteins
More stringent quality control standard: High sensitivity and specificity verified by FACS, no non-specific binding to non-transduced PBMCs, high batch-to-batch consistency and stability that meet the requirements of clinical sample analysis
Recommended: More pre-labeled proteins for different applications
>>>Find out more

Cytokine ELISA Kits
Suitable for the quantitative of cytokine in serum and cell matrix（RUO）

Self-development based on ACRO’s protein production platform, performance and supply ability and quality assured
High sensitivity, specificity and accuracy, strict method validation and quality control to ensure the within-run and between-run precision
Easy to use and high through put, at most 82 samples can be tested at one time in 2 hours
Customized service and antibodies materials are available Inquiry
>>>Find out more

Non-clinical studies/Clinical research

Pharmacokinetics (PK) research
CAR-T targets
Suitable for detecting CAR expression by flow cytometry in preclinical and clinical samples
More than 50 targets for solid tumor and blood tumor
Alexa Fluor/APC/PE/FITC/Biotin-labeled proteins are available
High stability and batch-to-batch consistency, performs well in flow cytometry in clinical trials
No non-specific binding to non-transduced PBMCs
Some products have completed the FDA DMF filing (DMF No.: 034936), which can support your IND, NDA, and BLA.
>>>Find out more

TCR-T targets
Suitable for detecting TCR by flow cytometry in preclinical and clinical trials
Monomer and tetramer are available for different application
High purity verified by SDS-PAGE; High affinity verified by SPR
High stability and batch-to-batch consistency
>>>Find out more
Anti-idiotypic Antibodies
Suitable for CAR expression by flow cytometry in preclinical and clinical samples
Featured anti-FMC63 antibody can specifically recognize the antigen-binding site of FMC63 derived CARs with high affinity
Suitable for detecting FMC63 derived anti-CD19 CARs in clinical trials
Overcome the challenges for complex cell components, low CAR-T cell concentration and non-specific background, etc.
Fluorescent-labeled products are available for one-step detection, reducing process time
Recommended: FM3-HPY53, FM3-FY45, FM3-BY54
>>>Find out more
>>>Anti-Idiotypic Antibody Development Service
Immunogenicity evaluation
Anti-idiotypic Antibodies
Suitable for detecting and characteristic of anti-drug antibodies
Monoclonal anti-idiotype antibody, polyclonal anti-idiotype antibody are available
Neutralizing antibodies, suitable for various ADA assay development(Direct/In-direct/Bridge ELISA,RIPA,SPR,Cell-based assay,Competitive Ligand Binding Assay)
Recommended products：FM3-S93, FM3-Y45A1
>>>Find out more

Anti-Idiotypic Antibody Development Service
ACRO provides cell therapy researchers with one-stop services from antigen preparation to polyclonal anti-idiotype antibody and immunogenicity test kit developments.>>>Find out more

Pharmacodynamic and safety studies
Cytokine ELISA Kits
Suitable for the quantitative of cytokine in serum and cell matrix（RUO）
Self-development based on ACRO’s protein production platform, performance and supply ability and quality assured
High sensitivity, specificity and accuracy, strict method validation and quality control to ensure the within-run and between-run precision
Easy to use and high through put, more than 82 samples can be tested at one time in 2 hrs
Customized service and antibodies materials are availableInquiry
>>>Find out more

PRODUCT LIST

  • GMP Grade Cytokines

  • Fluorescent-labeled Products

  • Targets for Cell Therapy

  • Anti-idiotypic Antibodies

  • Magnetic Beads

  • Nucleases

  • Cytokine ELISA Kits

Molecule Cat. No. Product Description Preorder/Order
IL-15 GMP-L15H13 GMP Human IL-15

Order

IL-7 GMP-L07H24 GMP Human IL-7

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IL-21 GMP-L21H25 GMP Human IL-21

Preorder

Fluorescent Labels Molecule Cat. No. Product Description Preorder/Order
Blood tumor
BCMA CD19 CD123 CD138 CD20 CD22 CD30 CD33 CD37 CD38 CD4 CD5 CD56 CD7 CD72 CD99 CLL-1 CS1 GPRC5D LILRB4
Solid tumor
VEGF R2 uPAR ROR1 PSMA PSCA NKG2D Nectin-4 MUC16 MUC1 MSLN IL13RA2 HGF R HER3 HER2 GUCY2C GPC3 FOLR1 FAP EpCAM EGFRVIII EGFR EBV DLL3 CLDN18 CEA CD70 CD47 CD147 CD133 CAIX B7-H3
TCR-T targets
NY-ESO-1
Molecule Cat. No. Antigen Neutralizing Activity Application
Adalimu*ab ADB-Y19 Anti-Adalimu*ab Antibodies (AY19) Neutralizing Antibody ADA assay; Neutralizing assay; Indirect ELISA
Adalimu*ab ADB-Y23b Anti-Adalimu*ab Antibodies (AY23b) (recommended for PK/PD) Non-Neutralizing Antibody PK bridging ELISA; Indirect ELISA
Bevacizu*ab BEB-Y10 Anti-Bevacizu*ab Antibodies (AY10) (MALS verified, recommended for PK/PD) Neutralizing Antibody PK bridging ELISA; Neutralizing assay; Indirect ELISA
Bevacizu*ab BEB-Y12 Anti-Bevacizu*ab Antibodies (AY12) (recommended for neutralizing assay) Neutralizing Antibody ADA assay; Neutralizing assay; Indirect ELISA
Bevacizu*ab BEB-Y9 Anti-Bevacizu*ab Antibodies (AY9) (recommended for ADA assay) Neutralizing Antibody ADA assay; Neutralizing assay; Indirect ELISA
Bevacizu*ab BEB-BY13 Biotinylated Anti-Bevacizu*ab Antibodies (AY13) (recommended for PK/PD) Neutralizing Antibody PK bridging ELISA;Neutralizing assay; Indirect ELISA
Cetuxi*ab CEB-Y27 Anti-Cetuxi*ab Antibodies (AY27) (recommended for ADA assay) Neutralizing Antibody ADA assay; Neutralizing assay; Indirect ELISA
Cetuxi*ab CEB-Y31 Anti-Cetuxi*ab Antibodies (AY31) (Non-Neutralizing) Non-Neutralizing Antibody ADA assay; Indirect ELISA
Cetuxi*ab CEB-Y29 Anti-Cetuxi*ab Antibodies (AY29) (recommended for PK/PD) Neutralizing Antibody PK bridging ELISA; Neutralizing assay; Indirect ELISA
Cetuxi*ab CEB-Y28 Anti-Cetuxi*ab Antibodies (AY28) Neutralizing Antibody ADA assay; Neutralizing assay; Indirect ELISA
Cetuxi*ab CEB-BY31 Biotinylated Anti-Cetuxi*ab Antibodies (AY31) (recommended for PK/PD) Non-Neutralizing Antibody PK bridging ELISA; Indirect ELISA
Rituxi*ab RIB-Y36 Anti-Rituxi*ab Antibodies (AY36) (recommended for ADA assay) Neutralizing Antibody ADA assay;Neutralizing assay; Indirect ELISA
Rituxi*ab RIB-Y37 Anti-Rituxi*ab Antibodies (AY37) (recommended for PK/PD) Neutralizing Antibody PK bridging ELISA;Neutralizing assay;Indirect ELISA
Rituxi*ab RIB-FY35c FITC-Labeled Anti-Rituxi*ab Antibodies, Mouse IgG1 Neutralizing Antibody ADA assay;Neutralizing assay; Indirect ELISA
Rituxi*ab RIB-Y35c Anti-Rituxi*ab Antibodies (MALS verified) Non-Neutralizing Antibody ADA assay; Indirect ELISA
Trastuzu*ab TRB-Y5b Anti-Trastuzu*ab Antibodies (AY5b) (recommended for PK/PD) Non-Neutralizing Antibody PK bridging ELISA
Trastuzu*ab TRB-Y1b Anti-Trastuzu*ab Antibodies (AY1b) (recommended for PK/PD) Neutralizing Antibody PK bridging ELISA; Neutralizing assay; Indirect ELISA
Cat. No. Product Description Application Preorder/Order
MBS-C001 Human T cell Activation/Expansion CD3/CD28 Beads, premium grade DMF Filed Cell activation and expansion

Order

Molecule Cat. No. Product Description Preorder/Order
Cas9 CA9-S5149 NLS-Cas9 Nuclease

Preorder

Cas12a CAA-L5149 NLS-Cas12a Nuclease

Order

BenzNuclease BEE-N3116 GENIUS™Nuclease DMF Filed

Order

Molecule Cat. No. Product Description
IFN-γ CRS-A017 Human Interferon-γ(IFN-γ) ELISA Kit
TNF-α CRS-A002 Human Tumor Necrosis Factor Alpha(TNF-α) ELISA Kit
IL-2 CRS-A003 Human Interleukin-2(IL-2) ELISA Kit
GM-CSF CRS-A013 Human Macrophage Colony Stimulating Factor 2(GM-CSF) ELISA Kit
IL-7 CRS-A006 Human Interleukin-7(IL-7) ELISA Kit
IL-15 CRS-A009 Human Interleukin-15(IL-15) ELISA Kit
IL-21 CRS-A010 Human Interleukin-21(IL-21) ELISA Kit

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