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1. Activation of FXR has an important role in maintaining glucose, lipid, and bile acid homeostasis in the enterohepatic system and preventing rat liver fibrosis as well as atherosclerosis, research showed that FXR agonists have marked renal protective effects. FXR agonists inhibit expression of SREBP-1, ChREBP and SREBP-2, resulting in decreased fatty acid and cholesterol synthesis and accumulation in the kidney.
2. Oral highly active and highly selective FXR agonist in-vitro, significantly improves diabetic nephropathy at a much lower dose than those of losartan and PX-102.
3. In vivo, show high absorption rate, high absolute bioavailability, high distribution concentration in kidney, fast clearance and mainly excreted in bile and feces.
1. Asset type: FXR agonist
2. Indication: Diabetic kidney disease
3. Modality: Small molecular
4. Research phase: Phase I is ongoing in China
5. Cooperation demands: Out licensing global right
6. Research progress：
Phase I clinical research is ongoing in China.
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