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1. Clear MOA
(1) The B7H3 protein (encoded from the CD276 gene) is a checkpoint molecule that is highly expressed in solid tumors, with reportedly limited expression in normal tissues. Overexpression of B7H3 is correlated with tumor progression, metastasis, and poor clinical outcome across a variety of malignancies.
(2) Monoclonal antibodies targeting B7H3 cause limited toxicity and have demonstrated some anti-tumor activity in clinical trials. Anti-B7H3 ADC can get better anti-tumor effect than anti-B7H3 mAb.
2. Antibodies specific binding to human B7H3 protein
Both anti-B7H3 are strong in binding to human B7H3. And anti-B7H3 #2’s affinity to mouse B7H3 is 100-fold weaker than Human B7H3.
3. High selectivity and affinity
(1) Both anti-B7H3’s cell-based affinity binding of 1-2 digit nano-molar was observed across cell lines. And No non-specific binding was observed on a target-negative cell line.
(2) No non-specific binding to other family members.
4. Induced strong B7H3 internalization on tumor cells.
5. Anti-B7H3 ADC showed strong potency in target-expressing cell lines, but weak potency in target-negative cell line, comparable to the isotype control ADC.
6. Good thermostability
1. Asset type: Anti-B7H3 ADC, 2 antibody sequences
2. Indication: Broad cancer
3. Modality: Small molecular
4. Research phase: Phase 1, IP has been granted in US, AU, CN
5. Cooperation demands: License-out or co-development
6. Research progress：
(1) Anti-B7H3 #2 (MMAE) ADC showed strong potency in target-expressing cell lines. Potency on a target-negative cell line was minimal and comparable to the isotype control ADC.
(2) Camptothecin ADCs: DAR8 conjugation was achieved. Both, Anti-B7H3 #1 and #2, showed some differential potency as Camptothecin ADCs over isotype control ADC in Calu-6 and HEC-251 cells.
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