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1. SGLT2 inhibitors have been identified as potential noninsulin glucose-lowering therapies for the management of diabetes. Glucose homeostasis involves reabsorption of filtered glucose by SGLTs at the proximal convoluted tubule of the kidney.
2. In STZ-induced diabetic hamsters, this candidate could decrease HbA1c and RPG in a dose-dependent manner, and the effect was better than that of Canagliflozin.
3. In STZ-induced diabetic hamsters, this candidate could decrease ACR and GSI in a dose-dependent manner, and the effect was better than that of Canagliflozin.
1. Asset type: SGLT2 inhibitor
2. Indication: Diabetes
3. Modality: Small molecular
4. Research phase: Phase III
5. Cooperation demands: Out licensing global right
6. Research progress：
(1) Given that clinical quantitative pharmacological data is based on the data in phase I, CDE agrees to exempt phase II and directly carry out phase III clinical research.
(2) Phase III clinical research was on going in China.
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To enable antibody characterization methodsACROBiosystems has developed a series of enzymes.such as ldeS, SpeB, EndoH, and Endo S proteases, toassist with the characterization of antibodies and theirrelated post-translational modifications (PTMs)
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