1. Clear MoA.
NGF is released upon injury and causes pain by activating its receptor TrkA on nociceptors and mast cells, leading to transmission of pain signals from the periphery to the spinal cord and brain via the dorsal ganglion. And the efficacies of anti-NGF have been validated clinically in a variety of pain conditions
2. Wide range of indications:Pain.
3. Excellent Phase I Data
(1). No dose-dependent AEs have been identified in Phase I.
(2). NGF mAb is expected to be administered every 8 weeks based on its PK profiles.
4. Global competitiveness.
The analgesic effect of NGF mAb is comparable to that of morphine, but it is not addictive.
The RPOA risk can be reduced by selecting cancer-related indications and excluding OA patients.
1. Asset type: Humanized NGF mAb
2. Indication: Cancer pain, chemotherapy-induced neuropathic pain, Kashin-Beck disease, diabetic neuralgia, interstitial cystitis, chronic low back pain.
3. Research phase: Phase Ⅰ/Ⅱa
4. Research progress:
1) Complete the first human trial.
2) Complete the single-dose escalation trial.
3) Complete the PK and safety trial:
NGF mAb is expected to be administered every 8 weeks based on its PK profiles.
No dose-dependent AEs have been identified in Phase I.
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