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1. Clear MoA.
1) Dual-blockade of PD-1 and SIRPα can activate potent antitumor effects via both innate and adaptive immune responses.
2) Anti-SIRPα drugs are a potential treatment for solid cancer because they can more easily enter into the solid tumor microenvironment through binding to peripheral macrophages.
3) SIRPα is only expressed on myeloid cells, not on erythrocytes. Unlike anti-CD47 drugs, Anti-SIRPα drugs do not cause erythrocytopenia.
2. High affinity.
The bsAb has high selectivity and high affinity to SIRPα and PD-1.
3. The bsAb can bridge PD-1 and SIRPα positive cells, while single or combination of antibodies can’t.
4. bsAb simultaneously release the inhibitory activity of DCs, T cells, and macrophages.
5. Better anti-tumor activity in vivo.
1) Excellent antitumor activity.
2) Great tumor immune memory in tumor recurrence model.
3) bsAb can polarize macrophages (decreased M2, increased M1) in the tumor microenvironment.
6. CMC ready: high purity (SEC ≥ 99%), good stability, great druggability.
1. Asset type: SIRPα×PD-1 bsAb
2. Indication: broad cancer
4. Research phase: Ready for CMC development
5. Cooperation demands: License-out or co-development
6. Research progress：
a) CMC stage: pilot production and toxicity test.
b) The bsAb binds specifically to SIRPα and PD-1 with high affinity.
c) The combination of SIRPα and PD-1 shows better activity than solitary target in vivo and remains active in the recurrence model due to great immune memory.
Explore our catalog of therapeutic antibody solutions to find the right products for you! We are dedicated to delivering solutions designed to help you drive innovation and push the boundaries of what therapeutic antibodies can be.
Organoid Toolbox is a collection of organoid solutions including ready-to-use organoids, organoid differentiation kits, and a variety of services to accelerate the progress of your drug development project.
To enable antibody characterization methodsACROBiosystems has developed a series of enzymes.such as ldeS, SpeB, EndoH, and Endo S proteases, toassist with the characterization of antibodies and theirrelated post-translational modifications (PTMs)
ACROBiosystems developed a series of GMP grade cytokines under the GMP grade quality management system. Those products are all suitable for T/NK cell generation, activation, and proliferation in cell therapy research.
50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process.
GMP grade cytokines, reagents for cell activation, gene edition, DNA/RNA removal, etc. Particularly focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey.
Full length multi-pass TPs with stabilized structure and high bioactivity for immunization, antibody screening, cell based assay and CAR detection, including hot CD20, Claudin 18.2， CD133, GPRC5D，CCR8, CCR5, etc.
A series of immune checkpoints including classic co-inhibitory and co-stimulatory receptors. The comprehensive catalog contains 100+ targets with various species and tags, and the high-quality proteins are in good batch-to-batch consistency.
To meet the needs of ADCs development, ACROBiosystems can provide: A variety of high-quality target proteins; MMPs/Cathepsin/uPA for cleavable linker; Anti-payload antibodies & anti-idiotypic antibodies for immunogenicity and PK analysis; SPR/BLI analytical and ADA development service.
Comprehensive collection of Fc receptor proteins, including their common variants, which can help expedite your antibody development.
Comprehensive cytokine targets including interleukins, growth factors, chemokines, TNFs, etc. are expressed by HEK293 to ensure their natural structure. Their high purity is verified by SDS-PAGE/HPLC/SEC-MALS and high bioactivity is verified by ELISA/SPR/BLI.
Aneuro provides innovative solutions for neuroscience research. Recombinant proteins, neural factors, pre-formed fibrils, electrophysiological electrodes, as well as Organoid Toolbox all in Aneuro aiming to advance neuroscience research, develop therapeutic interventions, and improve diagnostic methods for neurological diseases.
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