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1. Clear MoA.
1) LAG-3 belongs to the immunoglobulin (Ig) superfamily, it is a type I transmembrane protein with structural similarities to CD4.
2) LAG-3 is extensively expressed on activated T cells and NK cells，also expressed on activated B cells and plasma cell-like dendritic cells (pDCs).
3) LAG-3 is an inhibitory immune checkpoint for T cells, and like PD-1 and CTLA-4, LAG-3 negatively regulates the proliferation, activation, and homeostasis of T cells. It is a novel target for cancer and autoimmune disorders.
2. Excellent preclinical efficacy:
1) The binding activity of this LAG-3 mAb to human activated CD4 T cells is slightly higher than that of the positive control drug BH98 (Relatlimab analogue).
2) The blocking effect on FGL1 is higher than that of BH98.
3. Similar tumor-killing activity as Relatlimab (BH98) in vivo.
4. The combination of LAG-3 mAb and PD-1 can synergistically enhance the anti-tumor effect, better than monotherapy.
5. Excellent safety
1) NOAEL= 100 mg/kg.
2) No immunotoxicity: no ADCC activity
3) Plasma cytokine concentrations (IFNγ, TNFα, IL6, IL1β, IL2, IL4) were not abnormally increased after mAb administration.
4) No hemolytic effect.
1. Asset type: LAG-3 mAb
2. Indication: Advanced solid tumors
3. Research phase: Phase 1
4. Cooperation demands: License-out or co-development
5. Research progress：
1. Completed preclinical development
2. Phase I clinical trials are ongoing to evaluate the safety, tolerability, pharmacokinetics and efficacy of candidate antibodies for advanced malignancies.
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