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1. Clear MoA.
(1). Higher IL10 level in severe CRS, sepsis and HLH patients.
(2). Blocking IL10/IL10R signaling pathway is a new strategy of treating CRS, HLS, and sepsis.
lt is reported that a high ratio of lLl0 to TNFα correlated with mortality in patients (464 cases) with community-acquired infection.
2. Sepsis: high mortality (19 million patients, the mortality rate >25%), huge market size ($ 3.2 billion in 2018, with a CAGR of 7.5%).
3. Unique fully human mAb with low immunogenicity.
4. ADCC and ADCP silenced lgG4 ensures antibody safety.
5. Superior stability and good druggability.
After 6 times of frozen-thawing or storage at 40°C for 4 weeks, the activity of the candidate did not change significantly.
6. Both mAbs have blocking activity on lL10/IL10RA signal pathway, and the efficacy can be seen in the sepsis modeling mouse.
1. Asset type: IL10 / IL10RA mAb
2. Indication: Sepsis/ HLH/ CRS
3. Modality: fully human mAb, ADCC and ADCP silenced lgG4
4. Research phase: Ready for CMC development
5. Cooperation demands: License-out or co-development
6. Research progress：
(1). IL10 / IL10RA mAb showed excellent stability and good druggability.
(2). Ready for CMC development.
(3). IL10 / IL10RA mAb significantly prolonged the survival of mice with LPS-induced sepsis (90 % vs 30 %).
Explore our catalog of therapeutic antibody solutions to find the right products for you! We are dedicated to delivering solutions designed to help you drive innovation and push the boundaries of what therapeutic antibodies can be.
Organoid Toolbox is a collection of organoid solutions including ready-to-use organoids, organoid differentiation kits, and a variety of services to accelerate the progress of your drug development project.
To enable antibody characterization methodsACROBiosystems has developed a series of enzymes.such as ldeS, SpeB, EndoH, and Endo S proteases, toassist with the characterization of antibodies and theirrelated post-translational modifications (PTMs)
ACROBiosystems developed a series of GMP grade cytokines under the GMP grade quality management system. Those products are all suitable for T/NK cell generation, activation, and proliferation in cell therapy research.
50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process.
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To meet the needs of ADCs development, ACROBiosystems can provide: A variety of high-quality target proteins; MMPs/Cathepsin/uPA for cleavable linker; Anti-payload antibodies & anti-idiotypic antibodies for immunogenicity and PK analysis; SPR/BLI analytical and ADA development service.
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Comprehensive cytokine targets including interleukins, growth factors, chemokines, TNFs, etc. are expressed by HEK293 to ensure their natural structure. Their high purity is verified by SDS-PAGE/HPLC/SEC-MALS and high bioactivity is verified by ELISA/SPR/BLI.
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