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1. Clear MoA: High selectivity of inhibiting DHODH, Blocking the DHODH synthesis pathway can effectively inhibit the proliferation of activated immune cells and the secretion of cytokines.
2. Significant preclinical efficacy and less toxic & side effects.
1) Improve weight loss and disease activity score DIA in mice
2) Significant improvement in inflammation-induced increase in colon density and colonic weight gain
3) Anti-coronavirus activity
3. Global competitiveness:
BIC Potential. So far, there is no effective drug to cure IBD on the market, and the preclinical data of the target project is better than the fastest developing IMU-838.
4. Good market potential:
It is estimated that in 2025, the global IBD market will reach 11 billion US dollars. China will have more than 1.5 million IBD patients, and the drug market will be 16.6 billion yuan, with a compound annual growth rate of 14.26%.
1. Asset type: DHODH inhibitor
2. Indication: IBD, expanded indication COVID-19
3. Research phase: IND ready
4. Cooperation demands: License-out or co-development
5. Research progress：
1．Completed preclinical development and ready for IND filing.
2．In vitro study, all indicators of this DHODH inhibitor are equal to or better than IMU-838.
3．The selective inhibitor improved body weight loss and disease activity score DIA, and significantly improved inflammation-induced colon density and colon weight gain in a mouse model of IBD.
4．The safety test has been completed, and there are no obvious toxic and side effects.
Explore our catalog of therapeutic antibody solutions to find the right products for you! We are dedicated to delivering solutions designed to help you drive innovation and push the boundaries of what therapeutic antibodies can be.
Organoid Toolbox is a collection of organoid solutions including ready-to-use organoids, organoid differentiation kits, and a variety of services to accelerate the progress of your drug development project.
To enable antibody characterization methodsACROBiosystems has developed a series of enzymes.such as ldeS, SpeB, EndoH, and Endo S proteases, toassist with the characterization of antibodies and theirrelated post-translational modifications (PTMs)
ACROBiosystems developed a series of GMP grade cytokines under the GMP grade quality management system. Those products are all suitable for T/NK cell generation, activation, and proliferation in cell therapy research.
50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process.
GMP grade cytokines, reagents for cell activation, gene edition, DNA/RNA removal, etc. Particularly focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey.
Full length multi-pass TPs with stabilized structure and high bioactivity for immunization, antibody screening, cell based assay and CAR detection, including hot CD20, Claudin 18.2， CD133, GPRC5D，CCR8, CCR5, etc.
A series of immune checkpoints including classic co-inhibitory and co-stimulatory receptors. The comprehensive catalog contains 100+ targets with various species and tags, and the high-quality proteins are in good batch-to-batch consistency.
To meet the needs of ADCs development, ACROBiosystems can provide: A variety of high-quality target proteins; MMPs/Cathepsin/uPA for cleavable linker; Anti-payload antibodies & anti-idiotypic antibodies for immunogenicity and PK analysis; SPR/BLI analytical and ADA development service.
Comprehensive collection of Fc receptor proteins, including their common variants, which can help expedite your antibody development.
Comprehensive cytokine targets including interleukins, growth factors, chemokines, TNFs, etc. are expressed by HEK293 to ensure their natural structure. Their high purity is verified by SDS-PAGE/HPLC/SEC-MALS and high bioactivity is verified by ELISA/SPR/BLI.
Aneuro provides innovative solutions for neuroscience research. Recombinant proteins, neural factors, pre-formed fibrils, electrophysiological electrodes, as well as Organoid Toolbox all in Aneuro aiming to advance neuroscience research, develop therapeutic interventions, and improve diagnostic methods for neurological diseases.
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