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Your Position: Home > Antibody > IL-15 > IL5-PCFA1

PE-Labeled Monoclonal Anti-Human IL-15 Antibody, Mouse IgG1 (12B11E5) (0.03% Proclin)

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  • Source
    Monoclonal Anti-human IL-15 Antibody, Mouse IgG1 (12B11E5) is a mouse monoclonal antibody recombinantly expressed from human 293 cells (HEK293),which provides higher batch consistency and long term security of supply.
  • Application
    Flow Cytometry (Detection the expression of IL-15 on CAR-NK cells).
  • Clone
    12B11E5
  • Species
    Mouse
  • Isotype
    Mouse IgG1 | Mouse Kappa
  • Specificity
    This product is a specific antibody specifically reacts with Human IL-15.
  • Reactivity

    Human

  • Immunogen

    Recombinant Human IL-15 is expressed from human HEK293 cells.

  • Conjugate

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • Isotype Control

    The Isotype control is sold separately and you can search for Cat. No. DNP-PM1 for product information.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.3, 0.2% BSA, 0.03% Proclin300 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 24 months in lyophilized state;
    2. -70°C for 12 months after reconstitution.
    3. 2-8 °C for 12 month after reconstitution.
Bioactivity-ELISA
 IL-15 ELISA

Immobilized Human IL-15, His Tag (Cat. No. IL5-H52H8) at 1 μg/mL (100 μL/well) can bind PE-Labeled Monoclonal Anti-Human IL-15 Antibody, Mouse IgG1 (12B11E5) (Cat. No. IL5-PCFA1) with a linear range of 0.2-8 ng/mL (QC tested).

  • Background
    Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.
  • Clinical and Translational Updates

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Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:15 Details
  • Latest Research Phase:Phase 2 Clinical

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