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Your Position: Home > Protein > DLL4 > DL4-H5227

Human DLL4 Protein, His Tag, premium grade

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  • Synonym
    DLL4,Delta4
  • Source
    Human DLL4, His Tag, premium grade(DL4-H5227) is expressed from human 293 cells (HEK293). It contains AA Ser 27 - Pro 524 (Accession # Q9NR61-1 ).
    Predicted N-terminus: Ser 27
    It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage. When ready to transition into later clinical phases, we also offer a custom GMP protein service that tailors to your needs. We will work with you to customize and develop a GMP-grade product in accordance with your requests that also meets the requirements for raw and ancillary materials use in cell manufacturing of cell-based therapies.
  • Molecular Characterization
    DLL4 Structure

    This protein carries a polyhistidine tag at the C-terminus

    The protein has a calculated MW of 56.2 kDa. The protein migrates as 55-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 0.01 EU per μg by the LAL method.
  • Sterility
    The sterility testing was performed by membrane filtration method.
  • Mycoplasma
    Negative.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
DLL4 SDS-PAGE

Human DLL4, His Tag, premium grade on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
DLL4 MALS images

The purity of Human DLL4, His Tag, premium grade (Cat. No. DL4-H5227) is more than 90% and the molecular weight of this protein is around 56-76 kDa verified by SEC-MALS.

Bioactivity-ELISA
 DLL4 ELISA

Immobilized Human DLL4, His Tag, premium grade (Cat. No. DL4-H5227) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human DLL4 Antibody, Human IgG1 with a linear range of 0.1-4 ng/mL (QC tested).

 DLL4 ELISA

Immobilized Human NOTCH1, Fc Tag (Cat. No. NO1-H5255) at 5 μg/mL (100 μL/well) can bind Human DLL4, His Tag, premium grade (Cat. No. DL4-H5227) with a linear range of 0.078-1.25 μg/mL (Routinely tested).

  • Background
    Delta-like protein 4 (DLL4) is also known as Drosophila Delta homolog 4 (Delta4), which contains one DSL domain and eight EGF-like domains. DLL4 is expressed in vascular endothelium. DLL4 is involved in the Notch signaling pathway as Notch ligand, which can activates NOTCH1 and NOTCH4. DLL4 is involved in angiogenesis and negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. DLL4 can bind to Notch-1 and Notch-4.
  • Clinical and Translational Updates

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ETD of in-stock products: 2 business days

Price(USD) : $250.00

Price(USD) : $1540.00

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Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:3 Details
  • Latest Research Phase:Phase 3 Clinical

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