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Your Position: Home > Mesothelin

Mesothelin

Brief Information

Name:Mesothelin
Target Synonym:Pre-pro-megakaryocyte-potentiating factor,Mesothelin,MSLN,CAK1 Antigen,MPF,Soluble MPF Mesothelin Related Protein,Megakaryocyte Potentiating Factor,SMRP,CAK1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:33
Lastest Research Phase:Phase 2 Clinical

Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
CEA-B030 Human ClinMax™ Human Soluble Mesothelin ELISA Kit, PRO
SCCHO-ATP120 Human CHO/Human Mesothelin Stable Cell Line Development Service
CHEK-ATP119 Human HEK293/Human Mesothelin Stable Cell Line
MBS-C003 Human ActiveMax® Human MSLN μBeads, premium grade (for cells)
MSN-M5254 Mouse Mouse Mesothelin / MSLN Protein, Fc Tag
MSN-M5254-structure
MSN-M5254-sds
MSN-H5267 Human Human Mesothelin / MSLN (391-598) Protein, Fc Tag (MALS verified)
MSN-H5267-structure
MSN-H5267-sds
MSN-HA2H9 Human Alexa Fluor™ 488-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H9-structure
MSN-HA2H5 Human Alexa Fluor™ 647-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H5-structure
MSN-HA2H8 Human Alexa Fluor™ 555-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H8-structure
MSN-HA2H7 Human APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation)
MSN-HA2H7-structure
MSN-HA2H6 Human APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H6-structure
MSN-HP2H8 Human PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HP2H8-structure
MSN-HF2H3 Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HF2H3-structure
MSN-HF2H3-sds
MSN-H82E7 Human Biotinylated Human Mesothelin / MSLN (296-600) Protein, His,Avitag™ (MALS verified)
MSN-H82E7-structure
MSN-H82E7-sds
MSN-R52H4 Rat Rat Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-R52H4-structure
MSN-R52H4-sds
MBS-K024 Human Human Mesothelin-coupled Magnetic Beads
MSN-M82E7 Mouse Biotinylated Mouse Mesothelin / MSLN Protein, His,Avitag™
MSN-M82E7-structure
MSN-M82E7-sds
MSN-HP2H5 Human PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation)
MSN-C52H6 Cynomolgus Cynomolgus Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
MSN-C52H6-structure
MSN-C52H6-sds
MSN-M52H3 Mouse Mouse Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-M52H3-structure
MSN-M52H3-sds
MSN-HF25x Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF25x-structure
MSN-HF25x-sds
MSN-HR2P4 Human RFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HR2P4-structure
MSN-HR2P4-sds
MSN-HG2P4 Human GFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HG2P4-structure
MSN-HG2P4-sds
MSN-HF223 Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HF223-structure
MSN-HF223-sds
MSN-HF253 Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF253-structure
MSN-HF253-sds
MSN-H82F6 Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc,Avitag™, premium grade
MSN-H82F6-structure
MSN-H82F6-sds
MSN-H522a Human Human Mesothelin / MSLN (296-580) Protein, His Tag, premium grade
MSN-H522a-structure
MSN-H522a-sds
MSN-H5253 Human Human Mesothelin / MSLN (296-580) Protein, Fc Tag, premium grade
MSN-H5253-structure
MSN-H5253-sds
MSN-H82E9 Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™, premium grade
MSN-H82E9-structure
MSN-H82E9-sds
MSN-H826x Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc Tag, ultra sensitivity (primary amine labeling) (MALS verified)
MSN-H826x-structure
MSN-H826x-sds
MSN-H8223 Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, His Tag, ultra sensitivity (primary amine labeling)
MSN-H8223-structure
MSN-H8223-sds
MSN-H526x Human Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H526x-structure
MSN-H526x-sds
MSN-H5222 Human Human Mesothelin / MSLN (37-286) Protein, His Tag
MSN-H5222-structure
MSN-H5222-sds
ACRO Quality

Part of Bioactivity data

MSN-HA2H9-Cell-based assay
 Mesothelin CAR_T

5e5 of anti-MSLN CAR-293 cells were stained with 100 μL of 3 μg/mL of AF488-Labeled Human Mesothelin (296-580), His Tag (Cat. No. MSN-HA2H9) and negative control protein respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). AF488 signal was used to evaluate the binding activity (QC tested).

MSN-HR2P4-SPR
 Mesothelin SPR

Anti-human MSLN mAb (chimeric mouse-human IgG1) captured on CM5 chip via Anti-human IgG Fc antibodies surface, can bind RFP Fusion Human Mesothelin (296-580), His Tag (Cat. No. MSN-HR2P4) with an affinity constant of 0.304 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

MSN-HG2P4-SPR
 Mesothelin SPR

Anti-human MSLN MAb (chimeric mouse-human IgG1) captured on CM5 chip via Anti-human IgG Fc antibodies surface, can bind GFP Fusion Human Mesothelin (296-580), His Tag (Cat. No. MSN-HG2P4) with an affinity constant of 0.542 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Customer Reviews

Synonym Name

MSLN,Mesothelin,MPF

Background

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
RNA-Meso-CIR-T RNA-Meso-CIR-T Phase 1 Clinical Novartis Pharma Ag, University Of Pennsylvania Mesothelioma Details
Anti-mesothelin CAR-T (Pregene) Clinical Pregene (Shenzhen) Biotechnology Co Ltd Hydrothorax Details
Autologous Mesothelin-specific TCR-T Cell Therapy (Lonza Walkersville) Phase 1 Clinical Fred Hutchinson Cancer Research Center Pancreatic Neoplasms; Carcinoma, Pancreatic Ductal Details
Anti-mesothelin CAR-NK cell therapy(Guojianchengnuo) ALF-101 Phase 1 Clinical Guojianchengnuo Biotechnology (Beijing) Co Ltd Carcinoma, Ovarian Epithelial Details
HBM-9033 HBM-9033; HBM9033 Phase 1 Clinical Nona Biosciences Solid tumours Details
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute) Phase 2 Clinical Shanghai Cell Therapy Research Institute Neoplasms Details
Anetumab ravtansine BAY-94-9343; BAY-94-9343-SPDB-DM4; Anti-mesothelin antibody-drug conjugate BAY 94-9343 Phase 2 Clinical Bayer AG, Morphosys Ag Solid tumours; Ovarian Neoplasms; Cystadenocarcinoma, Serous; Pancreatic Neoplasms; Neoplasms; Mesothelioma; Peritoneal Neoplasms; Lung Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Endometrioid Details
anti-MESO CAR-T cells (Zhejiang University) UCLM802; UCLM-802 Phase 2 Clinical Zhejiang University, Hrain Biotechnology Co Ltd Ovarian Neoplasms; Solid tumours Details
UCMYM-802 UCMYM802; UCMYM-802 Phase 1 Clinical Solid tumours Details
Gavocabtagene autoleucel TC-210 Phase 2 Clinical Tcr2 Therapeutics Inc Ovarian Neoplasms; Mesothelioma; Cholangiocarcinoma; Carcinoma, Non-Small-Cell Lung Details
SynKIR-110 SynKIR™-110; SynKIR-meso Phase 1 Clinical Verismo Therapeutics Inc Ovarian Neoplasms; Mesothelioma; Cholangiocarcinoma Details
HPN-536 HPN-536 Phase 2 Clinical Harpoon Therapeutics Neoplasms Details
KT-032 KT-032 Phase 1 Clinical Nanjing Kati Medical Technology Co Ltd Ovarian Neoplasms; Solid tumours; Pancreatic Neoplasms; Mesothelioma Details
LD013 CAR T-cell therapy (Nanjing Landun Biotechnology) LD013; LD-013 Phase 1 Clinical Nanjing Landun Biotechnology Co Ltd Ovarian Neoplasms; Solid tumours Details
RC-88 RC-88 Phase 2 Clinical RemeGen Co Ltd Solid tumours; Carcinoma, Ovarian Epithelial; Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms Details
ABBV-428 ABBV-428; ABBV428 Phase 1 Clinical Abbvie Inc Solid tumours Details
iCasp9M28z iCasp9M28z Phase 2 Clinical Memorial Sloan Kettering Cancer Center Pleural Diseases; Mesothelioma; Breast Neoplasms; Lung Neoplasms; Neoplasm Metastasis Details
LMB-100 LMB-100; RG-7787; RO-6927005 Phase 2 Clinical F. Hoffmann-La Roche Ltd Carcinoma; Neoplasms, Mesothelial; Neoplasms; Pancreatic Neoplasms; Adenocarcinoma of Lung; Mesothelioma; Cholangiocarcinoma; Pleural Effusion, Malignant; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Autologous PD-1 antibody expressing mesothelin-targeted CAR-Tcells therapy (Shanghai Cell Therapy Research Institute) Phase 2 Clinical Shanghai Cell Therapy Research Institute Solid tumours Details
Anti-mesothelin CAR T cell therapy (UTC Therapeutics Inc) Phase 1 Clinical UTC Therapeutics Inc Solid tumours Details
GPC3/Mesothelin-CAR-γδT Cells therapy(Second Affiliated Hospital Of Guangzhou Medical University) Phase 1 Clinical Second Affiliated Hospital Of Guangzhou Medical University Solid tumours; Liver Neoplasms; Pancreatic Neoplasms; Mesothelioma; Lung Neoplasms Details
Inezetamab AMG-994 Phase 1 Clinical Amgen Inc Solid tumours Details
CART-meso CART-meso Phase 1 Clinical Novartis Pharma Ag, University Of Pennsylvania Ovarian Neoplasms; Carcinoma; Adenocarcinoma of Lung; Carcinoma, Ovarian Epithelial; Pancreatic Neoplasms; Mesothelioma; Breast Neoplasms; Fallopian Tube Neoplasms Details
A2B-694 A2B-694; A2B694 Phase 2 Clinical A2 Biotherapeutics Inc Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Rectal Neoplasms; Pancreatic Neoplasms; Neoplasms; Colonic Neoplasms; Mesothelioma; Colorectal Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
AB-1015 AB-1015 Phase 1 Clinical Arsenal Biosciences Inc Ovarian Neoplasms; Carcinoma, Ovarian Epithelial Details
PM-3006 PM-3006 Phase 1 Clinical Biotheus Inc Details
RD-133 RD133 Phase 1 Clinical Nanjing Iaso Biotherapeutics Co Ltd Solid tumours; Neoplasms Details
TCR-like CAR-T Cell Therapy(Zhongda Hospital Southeast University) Zhongda Hospital Southeast University Details
CD40 ligand expressing MSLN-CAR T cells Phase 2 Clinical Pla General Hospital Solid tumours Details
KD-021 KD-021 Phase 1 Clinical Nanjing Kaedi Biotechnology Co Ltd Neoplasms Details
AMG 305 AMG-305; AMG 305 Phase 1 Clinical Amgen Inc Solid tumours Details
Mesothelin-CAR-T Cells(Fapon Biopharma) FP-002 Fapon Biotech Inc Details
Anti-mesothelin thorium-227 labeled antibody chelator conjugate BAY-2287411 Phase 1 Clinical Bayer AG Ovarian Neoplasms; Mesothelioma; Carcinoma, Pancreatic Ductal Details
αPD1-MSLN-CAR T cell therapy (Shanghai Cell Therapy Group Co.,Ltd) BZDS1901; BZDS-1901; BZD1901 Phase 1 Clinical Shanghai Cell Therapy Group Co Ltd Ovarian Neoplasms; Solid tumours; Mesothelioma; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
RD-138 RD-138 Phase 1 Clinical Nanjing Iaso Biotherapeutics Co Ltd Multiple Myeloma Details

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