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Your Position: Home > Antibody > C-MET > HGS-S303

Recombinant Monoclonal Anti-C-MET Antibody, Rabbit (1A1)

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  • Background
    MET is a tyrosine kinase receptor for the hepatocyte growth factor. It is linked to functions such as cell proliferation, scattering, morphogenesis, and survival. Ligand binding at the cell surface induces autophosphorylation of MET that provides docking sites for downstream signaling molecules. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation.
  • Host Species

    Rabbit

  • Clone

    1A1

  • Application

    IHC

  • Property
    1:1000
  • State
    Liquid
  • Positive Control
    Human Placenta Tissue
  • Clonality
    Monoclonal
  • Synonym
    C-MET
  • Research Field
    Cancer Drug Targets
  • Source
    Rabbit
  • Isotype
    IgG
  • Storage
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Typical Data
Control Sample
 C-MET CONTROL SAMPLE

Immunohistochemical analysis of paraffin embedded Human placenta tissue labelled with HGS-S303 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Cancer Sample
 C-MET CANCER SAMPLE C-MET CANCER SAMPLE C-MET CANCER SAMPLE

Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HGS-S303 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

  • Clinical and Translational Updates

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Drug Development Status

  • Number of Launched Drugs:9 Details
  • Number of Drugs in Clinical Trials:61 Details
  • Latest Research Phase:Approved

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