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Your Position: Home > Antibody > CD45 (LCA) > HGS-S261

Recombinant Monoclonal Anti-CD45(LCA) Antibody, Rabbit (1C3)

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  • Background
    Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
  • Host Species

    Rabbit

  • Clone

    1C3

  • Application

    IHC

  • Property
    1:1000
  • State
    Liquid
  • Positive Control
    Human Tonsil Tissues
  • Clonality
    Monoclonal
  • Synonym
    PTPRC, CD45, GP180, LCA, T200
  • Research Field
    Cancer Drug Targets
  • Source
    Rabbit
  • Isotype
    IgG
  • Storage
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Typical Data
Control Sample
 CD45 (LCA) CONTROL SAMPLE

Immunohistochemical analysis of paraffin embedded Human tonsil tissue labelled with HGS-S261 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Cancer Sample
 CD45 (LCA) CANCER SAMPLE CD45 (LCA) CANCER SAMPLE CD45 (LCA) CANCER SAMPLE CD45 (LCA) CANCER SAMPLE

Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HGS-S261 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

  • Clinical and Translational Updates

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