Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > CLEC12A

CLEC12A

Brief Information

Name:C-Type lectin domain family 12 member A
Target Synonym:CD371 Antigen,C-Type Lectin-Like Molecule 1,MICL,CD371,CLEC12A,DCAL2,DCAL-2,Dendritic cell-associated lectin 2,C-Type Lectin Domain Family 12 Member A,Myeloid Inhibitory C-Type Lectin-Like Receptor,CLL-1,CLL1,C-Type Lectin Domain Family 12, Member A,C-Type Lectin-Like Molecule-1,C-Type Lectin Protein CLL-1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:21
Lastest Research Phase:Phase 3 Clinical

Product ListCompare or Buy

ACRO Quality

Part of Bioactivity data

CLA-HA246-Cell-based assay
 CLEC12A FACS

5e5 of Anti-CLEC12A/CLL-1 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human CLEC12A Protein, His Tag, premium grade (Cat. No. CLA-HA246) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).

CLA-HA248-Cell-based assay
 CLEC12A FACS

5e5 of anti-CLEC12A / CLL-1 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human CLEC12A, His Tag (Cat. No. CLA-HA248) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).

CLA-H82E6-ELISA
 CLEC12A ELISA

Immobilized Biotinylated Human CLEC12A Protein, Avitag,His Tag, premium grade (Cat. No. CLA-H82E6) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate, can bind Monoclonal Anti-Human CLEC12A Antibody, Human IgG1 with a linear range of 0.1-0.8 ng/mL (QC tested).

CLA-H5266-MALS-HPLC
CLEC12A MALS images

The purity of Human CLEC12A, Fc Tag (Cat. No. CLA-H5266) is more than 90% and the molecular weight of this protein is around 125-140 kDa verified by SEC-MALS.

Synonym Name

CLEC12A,MICL,CLL-1,CLL1,DCAL2,DCAL-2,CD371

Background

CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years.  The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ICG-136 ICG-136; 123b-33bcCAR Phase 1 Clinical Leukemia, Myeloid, Acute Details
CD123/CLL1 CAR-T Cell Therapy (Fujian Medical University) Fujian Medical University Details
CLL1 CAR-T(Zhejiang University) Phase 1 Clinical Zhejiang University Leukemia, Myeloid, Acute Details
CLL1+CD33 CAR-T(Zhejiang University) Phase 1 Clinical Zhejiang University Leukemia, Myeloid, Acute Details
CLL1-CD33 cCART cell therapy (iCell Gene Therapeutics) CLL1-CD33-cCAR Phase 1 Clinical Chengdu Military General Hospital Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Hematologic Neoplasms; Myelodysplastic Syndromes; Myeloproliferative Disorders; Leukemia, Myeloid, Acute Details
CLL1 CAR T-cell Therapy(Yake Biotechnology) Phase 1 Clinical Shanghai YaKe Biotechnology Co Ltd Leukemia, Myeloid, Acute Details
Anti-CLL1 CAR T cell therapy(Soochow University) Phase 2 Clinical The First Affiliated Hospital Of Soochow University Leukemia, Myeloid, Acute Details
CLL-1.CAR T cell therapy (Baylor College of Medicine) Phase 1 Clinical Baylor College Of Medicine Leukemia, Myeloid, Acute Details
Anti-CD33/CLL1 CAR-NK Cell Therapy Phase 1 Clinical Imbioray (Hangzhou) Biomedicine Co Ltd Leukemia, Myeloid, Acute Details
KITE-222 Phase 1 Clinical Kite Pharma Leukemia, Myeloid, Acute Details
Anti-CD33/CLL-1 CAR-T (Legend) Phase 1 Clinical Legend Biotech Corp Leukemia, Promyelocytic, Acute Details
Tepoditamab MCLA-117 Phase 1 Clinical Pharmaceutical Research Associates, Institute Gustave-Roussy, Merus Nv, Vu University Medical Center, Lgc Leukemia, Myeloid, Acute Details

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA

Leave a message