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TrkA

Brief Information

Name:Nerve growth factor receptor Trk-A
Target Synonym:NTRK1,Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tyrosine kinase receptor A,TRKA,Trk-A,Tyrosine kinase receptor,EC:2.7.10.1,High Affinity Nerve Growth Factor Receptor,EC 2.7.10,Neurotrophic Receptor Tyrosine Kinase 1,Neurotrophic Tyrosine Kinase, Receptor, Type 1,Tropomyosin-Related Kinase A,P140-TrkA,Gp140trk,MTC,TRK,Oncogene TRK,EC 2.7.10.1,TRK1,Receptor, trkA
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:20
Lastest Research Phase:Approved

Licensing

Project Name Modality Therapeutic Area Indications Stage Right Available
NGF mAb Monospecific antibody Neurological disease Cancer pain Phase II Global  (except China)

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Cat. No. Species Product Description Structure Purity Feature
TRA-H5253 Human Human TrkA / NTRK1 (192-402) Protein, Mouse IgG2a Fc Tag
TRA-H5253-structure
TRA-H5253-sds
TRA-H5259 Human Human TrkA / NTRK1 (33-417) Protein, Mouse IgG2a Fc Tag
TRA-H5259-structure
TRA-H5259-sds
ACRO Quality

Synonym Name

TrkA,NTRK1,MTC,TRK,TRKA,Trk-A

Background

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Entrectinib NMS-E628; RXDX-101; RG-6268 Approved Nerviano Medical Sciences Srl 罗圣全, Rozlytrek Japan Carcinoma, Non-Small-Cell Lung Chugai Pharmaceutical Co Ltd 2019-06-18 Sarcoma; Thyroid Cancer, Papillary; Melanoma; Carcinoma, Non-Small-Cell Lung; Lymphoma, Large-Cell, Anaplastic; Leukemia, Myeloid, Acute; Glioma; Hepatic Insufficiency; Colorectal Neoplasms; Lymphoproliferative Disorders; Breast Neoplasms; Cholangiocarcinoma; Solid tumours; Brain Neoplasms; Neuroendocrine Tumors; Central Nervous System Neoplasms; Pancreatic Neoplasms; Salivary Gland Neoplasms; Neoplasms; Carcinoma, Renal Cell; Head and Neck Neoplasms; Ovarian Neoplasms; Skin Melanoma; Hematologic Neoplasms Details
Larotrectinib sulfate LOXO-101; ARRY-470; BAY-2757556 Approved Array Biopharma Vitrakvi, 维泰凯 United States Solid tumours Bayer Healthcare Pharmaceuticals Inc 2018-11-26 Glioma; Neuroblastoma; Sarcoma; Sarcoma, Ewing; Osteosarcoma; Histiocytosis, Langerhans-Cell; Cholangiocarcinoma; Breast Neoplasms; Prostatic Neoplasms; Histiocytic Sarcoma; Colorectal Neoplasms; Lymphoma, Non-Hodgkin; Carcinoma, Squamous Cell; Multiple Myeloma; Uterine Neoplasms; Lung Neoplasms; Endometrial Neoplasms; Lymphoma; Esophageal adenocarcinoma; Neoplasms, Neuroepithelial; Thyroid Neoplasms; Neuroectodermal Tumors, Primitive, Peripheral; Neoplasms, Germ Cell and Embryonal; Xanthogranuloma, Juvenile; Uterine Cervical Neoplasms; Melanoma; Stomach Neoplasms; Solid tumours; Leukemia; Ependymoma; Medulloblastoma; Rhabdomyosarcoma; Liver Neoplasms; Head and Neck Neoplasms; Ovarian Neoplasms; Hepatoblastoma; Rhabdoid Tumor; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Fibrosarcoma; Esophageal Neoplasms; Rectal Neoplasms; Wilms Tumor; Skin Neoplasms; Carcinoma, Ovarian Epithelial; Colonic Neoplasms; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Neoplasms; Central Nervous System Neo Details
Regorafenib DAST; BAY-73-4506 Approved Bayer AG Stivarga, Resihance United States Colorectal Neoplasms Bayer Healthcare Pharmaceuticals Inc 2012-09-27 Esophageal adenocarcinoma; Osteosarcoma; Sarcoma, Ewing; Bile Duct Neoplasms; Peritoneal Neoplasms; Bone Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Fallopian Tube Neoplasms; Lung Neoplasms; Thyroid Neoplasms; Sarcoma; Leukemia, Myeloid, Acute; Thymoma; Melanoma; Gastrointestinal Neoplasms; Carcinoma, Hepatocellular; Adenocarcinoma; Somatostatinoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Solid tumours; Liver Neoplasms; Carcinoid Tumor; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Islet Cell; Insulinoma; Hemangiosarcoma; Rectal Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms; Pancreatic Neoplasms; Colonic Neoplasms; Neoplasms; Glioblastoma; Carcinoma, Transitional Cell; Glucagonoma; Carcinoma, Adenoid Cystic; Adenoma; Gastrinoma Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
VMD-928 VMD-928 Phase 1 Clinical Vm Oncology Llc Leiomyosarcoma; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Colonic Neoplasms; Pancreatic Neoplasms; Urinary Bladder Neoplasms; Carcinoma, Adenoid Cystic; Mesothelioma; Gallbladder Neoplasms; Thymoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
AK-1830 AK-1830 Phase 1 Clinical Array Biopharma Inflammation Details
Tavilermide MIM-D3; NMG938VJ6T (UNII code) Phase 3 Clinical Mimetogen Pharmaceuticals Keratoconjunctivitis Sicca; Dry Eye Syndromes Details
Merestinib 5OGS5K699E; LY-2801653 Phase 2 Clinical Eli Lilly And Company Biliary Tract Neoplasms; Skin Melanoma; Bone metastases; Solid tumours; Neoplasms; Pancreatic Neoplasms; Microsatellite instability-high cancer; Breast Neoplasms; Lymphoma, Mantle-Cell; Cholangiocarcinoma; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Gallbladder Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
HG-030 HG-030 Phase 1 Clinical Hitgen Inc Solid tumours Details
XZP-5955 XZP-5955 Phase 2 Clinical Xuanzhu (Shijiazhuang) Biotechnology Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details
FCN-098 FCN-098; FCN098 Phase 1 Clinical Fochon Pharmaceuticals Ltd, Fochon Pharmaceuticals Ltd Solid tumours; Neoplasms Details
TQB-3558 TQB-3558; CT-3417 Phase 1 Clinical Beijing Centaurus Biopharma Co Ltd, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd Solid tumours Details
ND-003 (newdel) ND-003 Phase 1 Clinical Shenzhen NewDEL Biotech Co Ltd, Shenzhen Innovation Center for Small Molecule Drug Discovery Co Ltd Solid tumours; Neoplasms; Idiopathic Pulmonary Fibrosis; Renal fibrosis Details
E-2511 E2511; E-2511 Phase 1 Clinical Eisai Inc Details
ACD-856 ACD-856 Phase 1 Clinical Alzecure Pharma Ab Alzheimer Disease; Cognition Disorders Details
Milciclib maleate PHA-848125; TZLS-201; PHA-848125C; PHA-125; PHA-848125AC Phase 2 Clinical Tiziana Life Sciences Plc, Nerviano Medical Sciences Srl Solid tumours; Thymoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
SNA-125 CT-340; SNA-125 Phase 2 Clinical Sienna Biopharmaceuticals Inc, Creabilis Sa Pruritus; Psoriasis; Dermatitis, Atopic Details
BEN-2293 BEN-00002293; BEN-2293 Phase 2 Clinical Benevolentai Bio Ltd Dermatitis, Atopic Details
PBI-200 Phase 2 Clinical Pyramid Biosciences Solid tumours; Desmoplastic Small Round Cell Tumor; Brain Neoplasms Details
TQB-3811 TQB-3811; CT-3872 Phase 1 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd, Beijing Centaurus Biopharma Co Ltd Solid tumours Details
VC-004 VC004; VC-004; VC 004 Phase 2 Clinical Jiangsu Vcare Pharmatech Co Ltd Solid tumours; Pruritus; Cancer Pain; Dermatitis; Neoplasm Metastasis Details
Lestaurtinib SPM-924; A-154475.0; KT-5555; SP-924; CEP-701 Phase 3 Clinical Kyowa Hakko Kirin Co Ltd Leukemia, Myeloid; Bone Marrow Neoplasms; Leukemia; Polycythemia Vera; Prostatic Neoplasms; Psoriasis; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Neuroblastoma; Primary Myelofibrosis; Leukemia, Myeloid, Acute; Thrombocythemia, Essential Details
BR-01T BR01T; BR-01T Phase 1 Clinical Xiyuan Anjian Pharmaceutical (Shanghai) Co Ltd Low Back Pain Details

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