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Your Position: Home > Jagged 1

Jagged 1

Brief Information

Name:Protein jagged-1
Target Synonym:AHD,AWS,AGS,Jagged-1 Protein,Jagged1,Protein jagged-1,JAG1,Jagged 1,JAGL1,Alagille Syndrome,CD339,AGS1,DCHE,Jagged Canonical Notch Ligand 1,hJ1,CD339 Antigen
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
JA1-H52H9 Human Human Jagged 1 / JAG1 Protein, His Tag
JA1-H52H9-structure
JA1-H52H9-sds
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Part of Bioactivity data

JA1-H52H9-SPR
Jagged 1 SPR

Human Jagged 1 Protein, His Tag (Cat. No. JA1-H52H9) immobilized on CM5 Chip can bind Human NOTCH1, Fc Tag (Cat. No. NO1-H5255) with an affinity constant of 5.13 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Customer Reviews

Synonym Name

CD339,JAG1,Jagged1,hJ1,JAGL1

Background

Protein jagged-1 (JAG1) is also known as Jagged1, hJ1, JAGL1 and CD339, which is a single-pass type I membrane protein containing one DSL domain and 15 EGF-like domains. JAG1 is widely expressed in adult and fetal tissues,the expression of JAG1 is up-regulated in cervical squamous cell carcinoma and also expressed in bone marrow cell line HS-27a.JAG1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. JAG1 is involved in early and late stages of mammalian cardiovascular development. JAG1 inhibits myoblast differentiation by similarity and enhances fibroblast growth factor-induced angiogenesis (in vitro).

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AMG-430 AMG-430 Phase 1 Clinical Amgen Inc Cystic Fibrosis; Pulmonary Disease, Chronic Obstructive Details

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