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HGF R

Brief Information

Name:Hepatocyte growth factor receptor
Target Synonym:EC 2.7.10,EC:2.7.10.1,HGF receptor,HGF/SF receptor,Hepatocyte growth factor receptor,Tyrosine-protein kinase Met,MET,SF receptor,Scatter factor receptor,MET Proto-Oncogene, Receptor Tyrosine Kinase,Proto-Oncogene C-Met,Met Proto-Oncogene,EC 2.7.10.1,DFNB97,AUTS9,RCCP2,C-Met,HGFR,Proto-Oncogene Proteins c-met
Number of Launched Drugs:9
Number of Drugs in Clinical Trials:59
Lastest Research Phase:Approved

Licensing

Project Name Modality Therapeutic Area Indications Stage Right Available
c-Met/AXL inhibitor Small molecule Oncology/Cancer Gastric cancer Phase I Global

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Part of Bioactivity data

CHEK-ATP146-Cell-based assay
 HGF R FACS

Expression analysis of human c-MET on HEK293/Human c-MET Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human c-MET Stable Cell Line or negative control cell using PE-labeled anti-human c-MET antibody.

CHEK-ATF144-Cell-based assay
 HGF R FACS

Expression analysis of human c-MET on Human c-MET (Luc) HEK293 Reporter Cell by FACS.
Cell surface staining was performed on Human c-MET (Luc) HEK293 Reporter Cell or negative control cell using PE-labeled anti-human c-MET antibody.

MET-C52H9-ELISA
 HGF R ELISA

Immobilized Cynomolgus HGF R, His Tag (Cat. No. MET-C52H9) at 5 μg/mL (100 μL/well) can bind Human HGF, Fc Tag (Cat. No. HGF-H5253) with a linear range of 0.6-20 ng/mL (QC tested).

MET-R52H9-MALS-HPLC
HGF R MALS images

The purity of Rabbit HGF R Protein, His Tag (Cat. No. MET-R52H9) is more than 85% and the molecular weight of this protein is around 103-125 kDa verified by SEC-MALS.

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Synonym Name

MET,AUTS9,HGFR,RCCP2,c-Met

Background

The SARS-CoV-2 Spike S2-coupled Magnetic Beads is produced by coupling biotinylated SARS-CoV-2 spike S2 protein to streptavidin-conjugated magnetic beads. Because Streptavidin (SA) has an extraordinarily high affinity for biotin with a dissociation constant (Kd) on the order of 10-14 mol/L, the biotinylated protein can bind to the SA beads irreversibly. The pre-coupled beads are ready to use for capturing anti-SARS-CoV-2 antibody or ACE2 protein from your sample with high specificity.

Clinical and Translational Updates

Related Molecule

HGF

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Glumetinib HH-SCC244; SCC244; SCC-244 Approved Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, Shanghai Greenvalley Pharmaceutical Co Ltd 海益坦 Mainland China Carcinoma, Non-Small-Cell Lung ShangHai HaiHe Biopharma Co Ltd 2023-03-07 Solid tumours; Carcinoma, Non-Small-Cell Lung Details
Cabozantinib S-malate XL-184; BMS-907351 Approved Exelixis Inc Cometriq, Cabometyx United States Carcinoma, Neuroendocrine; Thyroid Neoplasms Exelixis Inc 2012-11-29 Carcinoma, Adenosquamous; Uterine Neoplasms; Thyroid Neoplasms; Hepatic Insufficiency; Gliosarcoma; Bile Duct Neoplasms; Peritoneal Neoplasms; Astrocytoma; Colorectal Neoplasms; Brain Neoplasms; Endometrial Neoplasms; Osteosarcoma; Urethral Neoplasms; Adenocarcinoma, Clear Cell; Neuroblastoma; Neurofibroma, Plexiform; Cholangiocarcinoma; Medullary thyroid cancer (MTC); Sarcoma, Ewing; Breast Neoplasms; Carcinoma, Endometrioid; Neoplasms, Germ Cell and Embryonal; Meningioma; Melanoma; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Thyroid Cancer, Papillary; Neoplasm Metastasis; Paraganglioma; Carcinoma, Hepatocellular; Sarcoma, Clear Cell; Carcinoma, Neuroendocrine; Fallopian Tube Neoplasms; Brain metastases; Lymphoma; Leukemia, Myeloid, Acute; Sarcoma, Alveolar Soft Part; Glioma; Carcinoma, Squamous Cell; Pain; Adrenal Cortex Neoplasms; Pancreatic neuroendocrine tumors (pNET); Glioblastoma; Kidney Diseases; Hepatoblastoma; Pheochromocytoma; Carcinoma, Renal Cell; Rejection of liver transplantation; Carcinoid Details
Capmatinib Hydrochloride NVP-INC280-NX; INCB-28060; C2A374O70X; INC-280; INCB-028060 Approved Incyte Corp, Novartis Pharma Ag Tabrecta United States Carcinoma, Non-Small-Cell Lung Novartis Pharmaceuticals Corp 2020-05-06 Glioblastoma; Carcinoma, Hepatocellular; Melanoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Gliosarcoma; Colorectal Neoplasms; Sarcoma; Liver Neoplasms; Adenocarcinoma of Lung; Triple Negative Breast Neoplasms; Neoplasms; Carcinoma, Renal Cell; Carcinoma; Kidney Neoplasms; Skin Melanoma; Solid tumours Details
Amivantamab CNTO4424; CNTO-4424; JNJ-61186372; JNJ-372; JNJ-6372 Approved Genmab A/S RYBREVANT United States Carcinoma, Non-Small-Cell Lung Janssen Biotech Inc 2021-05-21 Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details
Ensartinib Hydrochloride X-396 Approved Xcovery 贝美纳 Mainland China Carcinoma, Non-Small-Cell Lung Betta Pharmaceuticals Co Ltd 2020-11-17 Sarcoma, Ewing; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Xanthogranuloma, Juvenile; Neuroectodermal Tumors, Primitive, Peripheral; Neoplasms, Germ Cell and Embryonal; Brain metastases; Neoplasms, Neuroepithelial; Lymphoma, Non-Hodgkin; Carcinoma, Squamous Cell; Glioma; Lung Neoplasms; Histiocytic Sarcoma; Rhabdomyosarcoma; Osteosarcoma; Histiocytosis, Langerhans-Cell; Neuroblastoma; Sarcoma; Central Nervous System Neoplasms; Neoplasms; Wilms Tumor; Hepatoblastoma; Rhabdoid Tumor; Solid tumours; Medulloblastoma; Ependymoma Details
Savolitinib HM-5016504; AZD-6094; HMP-504; HMPL-504 Approved Hutchison Medipharma Ltd 沃瑞沙, ORPATHYS Mainland China Carcinoma, Non-Small-Cell Lung Hutchison Medipharma Ltd 2021-06-22 Central Nervous System Neoplasms; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Neoplasms, Neuroepithelial; Glioma; Carcinoma, Squamous Cell; Urologic Neoplasms; Diffuse Intrinsic Pontine Glioma; Colorectal Neoplasms; Peritoneal Neoplasms; Cholangiocarcinoma; Medulloblastoma; Kidney Diseases; Colonic Neoplasms; Neoplasms; Carcinoma; Stomach Neoplasms; Esophageal Neoplasms; Rectal Neoplasms; Carcinoma, Renal Cell; Kidney Neoplasms; Solid tumours Details
Vebreltinib CBI-3103; PLB-1001; CBT-101; APL-101 Approved Crown Bioscience Inc Mainland China Carcinoma, Non-Small-Cell Lung Beijing Purunao Biotechnology Co Ltd 2023-11-16 Solid tumours; Kidney Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Ganglioglioma; Neoplasms; Pancreatic Neoplasms; Glioblastoma; Colonic Neoplasms; Brain Neoplasms; Glioma; Thyroid Neoplasms; Lung Neoplasms; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung Details
Crizotinib PF-1066; PF-2341066; PF-02341066; PF-002341066 Approved Pfizer Pharmaceuticals Ltd (China) 赛可瑞, Xalkori United States Carcinoma, Non-Small-Cell Lung Pf Prism Cv 2011-08-26 Urethral Neoplasms; Neurilemmoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Granuloma, Plasma Cell; Lymphoma; Endometrial Neoplasms; Lymphoma, Large-Cell, Anaplastic; Lung Neoplasms; Ureteral Neoplasms; Neuroblastoma; Hematologic Neoplasms; Lymphoma, Primary Cutaneous Anaplastic Large Cell; Multiple Myeloma; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms; Uveal melanoma; Myofibroma; Neurofibromatosis 2; Kidney Diseases; Neoplasms; Solid tumours Details
Tepotinib hydrochloride hydrate MSC-2156119J; MSC-2156119; EMD-1214063 Approved Merck Serono Tepmetko, テプミトコ, TEPMETKO Japan Carcinoma, Non-Small-Cell Lung Merck KGaA, Darmstadt, Germany 2020-03-25 Solid tumours; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SAIT-301 SAIT-301 Phase 1 Clinical Samsung Medical Center Neoplasms Details
Emibetuzumab LA-480; LY-2875358 Phase 2 Clinical Eli Lilly And Company Solid tumours; Liver Neoplasms; Esophageal Neoplasms; Carcinoma, Renal Cell; Stomach Neoplasms; Neoplasms; Lymphoma; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
ASKC-202 ASKC202 Phase 1 Clinical Jiangsu Aosaikang Pharmaceutical Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details
CKD-702 Phase 2 Clinical Chong Kun Dang Pharmaceutical Corp Stomach Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Kanitinib CX-1003 Phase 1 Clinical Beijing Konruns Pharmaceutical Co Ltd, Guangzhou Yingsheng Bio Technology Co Ltd Solid tumours Details
[111In]-FPI-2107 [111In]-FPI-2107 Phase 1 Clinical Fusion Pharmaceuticals Inc, Astrazeneca Plc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details
NP-01 (Shijiazhuang No.4 Pharmaceutical/Nanjing Nadingfei Medical Technology) NP-01 Phase 1 Clinical Shijiazhuang No 4 Pharmaceutical Co Ltd, Nanjing Nadingfei Pharmaceutical Technology Co Ltd Solid tumours; Liver Neoplasms; Stomach Neoplasms; Lung Neoplasms Details
Davutamig REGN-5093 Phase 2 Clinical Regeneron Pharmaceuticals Inc Carcinoma, Non-Small-Cell Lung Details
Pamvatamig MCLA-129 Phase 2 Clinical Merus Nv Solid tumours; Head and Neck Neoplasms; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung Details
HS-20117 HS-20117; PM1080; PM-1080 Phase 1 Clinical Biotheus Inc Solid tumours; Carcinoma, Non-Small-Cell Lung Details
HS-10241 HS-10241 Phase 3 Clinical Jiangsu Hansoh Pharmaceutical Group Co Ltd Solid tumours; Carcinoma; Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Tivantinib ARQ-197 Phase 2 Clinical Arqule Inc Mesothelioma; Neoplasms, Germ Cell and Embryonal; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Sarcoma, Alveolar Soft Part; Hepatic Insufficiency; Colorectal Neoplasms; Prostatic Neoplasms; Breast Neoplasms; Sarcoma; Multiple Myeloma; Solid tumours; Triple Negative Breast Neoplasms; Neoplasms; Pancreatic Neoplasms; Fibrosis; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Liver Neoplasms Details
Merestinib 5OGS5K699E; LY-2801653 Phase 2 Clinical Eli Lilly And Company Biliary Tract Neoplasms; Skin Melanoma; Bone metastases; Solid tumours; Neoplasms; Pancreatic Neoplasms; Microsatellite instability-high cancer; Breast Neoplasms; Lymphoma, Mantle-Cell; Cholangiocarcinoma; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Gallbladder Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
HQP8361 HQP-8361; APG-8361; MK-8033 Phase 1 Clinical Merck & Co Inc Solid tumours Details
Glesatinib MGCD-265; MG-90265X; 7Q29OXD98N; MG-90265H9; MG-90265gly; MG-90265 Phase 2 Clinical Mirati Therapeutics Inc Neoplasms; Carcinoma, Non-Small-Cell Lung Details
QBH-196 QBH-196 Phase 1 Clinical Shenyang Pharmaceutical University Solid tumours; Stomach Neoplasms Details
Recombinant adenovirus-hepatocyte growth factor(Institute Of Radiation And Radiation Medicine, Chinese Academy Of Military Medical Sciences) Phase 2 Clinical Institute Of Radiation And Radiation Medicine, Chinese Academy Of Military Medical Sciences, Beijing Haitai United Pharmaceutical Technology Development Co Ltd Myocardial Ischemia Details
ANS-014004 ANS014004; ANS-014004; ANS-01; ANS01 Phase 1 Clinical Neoplasms Details
EMI-137 EMI-137; GE-137 Phase 2 Clinical Ge Healthcare Esophageal Neoplasms; Colonic Neoplasms; Extranodal Extension; Barrett Esophagus Details
Pamufetinib TAS-115 Phase 1 Clinical Taiho Pharmaceutical Co Ltd, Otsuka Pharmaceutical Co Ltd Neoplasms Details
Elzovantinib TPX-0022 Phase 2 Clinical Solid tumours; Stomach Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
Bafisontamab FIT-013a; EMB-01 Phase 2 Clinical Shanghai Epimab Biotherapeutics, Inc Biliary Tract Neoplasms; Liver Neoplasms; Carcinoid Tumor; Stomach Neoplasms; Neoplasms; Digestive System Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Neoplasm Metastasis; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details
Metatinib Trometamol BMS-817378; SIM-817378 Phase 1 Clinical Bristol-Myers Squibb Company Solid tumours; Liver Neoplasms; Stomach Neoplasms; Colorectal Neoplasms Details
CBT-101 CBT-101 Phase 1 Clinical Crown Bioscience Inc Solid tumours Details
AL-2846 AL-2846 Phase 3 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd, Advenchen Laboratories Nanjing Ltd Pancreatic Neoplasms; Neurofibromatosis 1; Carcinoma, Non-Small-Cell Lung; Neurilemmoma; Lung Neoplasms; Thyroid Neoplasms; Colorectal Neoplasms; Prostatic Neoplasms; Medullary thyroid cancer (MTC); Solid tumours; Neurofibroma; Neoplasms; Ganglioglioma; Neurofibromatoses; Stomach Neoplasms; Bone metastases; Ovarian Neoplasms; Liver Neoplasms Details
NPS-1034 HOPE-777; KDDF-201111-02 Neopharma Ltd Details
FPI-2053 FPI-2053 Phase 1 Clinical Fusion Pharmaceuticals Inc, Astrazeneca Plc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details
REGN-5093-M114 METxMET-M114; REGN5093-M114 Phase 2 Clinical Regeneron Pharmaceuticals Inc Carcinoma, Non-Small-Cell Lung Details
BYON-3521 BYON-3521 Phase 1 Clinical Byondis Bv Solid tumours; Neoplasms Details
LMV-12(HE003) LMV-12(HE003) Phase 1 Clinical Nanchang Hongyi Technology Co Ltd Solid tumours Details
HLX-55 HLX-55; KTN-0216 Phase 1 Clinical Kolltan Pharmaceuticals Inc Solid tumours Details
Ningetinib Tosylate CT-053-PTSA; CT-053 Phase 2 Clinical Hec Pharm Co Ltd Intestinal Neoplasms; Solid tumours; Carcinoma, Renal Cell; Stomach Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
AZD9592 AZD-9592; AZD9592 Phase 1 Clinical Astrazeneca Plc Solid tumours; Head and Neck Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
NP-107 NP107; NP-107 Phase 1 Clinical Shanghai Nawei Biotechnology Co Ltd Solid tumours Details
ATH-1020 ATH-1020 Phase 1 Clinical Athira Pharma Inc Details
Zanzalintinib XL-092 Phase 3 Clinical Exelixis Inc Solid tumours; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
Sitravatinib MG-91516; MGCD-516; IND-155305; MG-516 Phase 3 Clinical Mirati Therapeutics Inc Breast Neoplasms; Carcinoma, Hepatocellular; Gastrointestinal Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Mouth Neoplasms; Endometrial Neoplasms; Carcinoma, Squamous Cell; Esophageal Squamous Cell Carcinoma; Ureteral Neoplasms; Hepatic Insufficiency; Solid tumours; Liposarcoma; Uveal melanoma; Lung Diseases; Carcinoma, Transitional Cell; Triple Negative Breast Neoplasms; Neoplasms; Carcinoma; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Biliary Tract Neoplasms; Kidney Neoplasms Details
ABN-401 ABN-401; KDDF-201603-08 Phase 2 Clinical Abion Inc Solid tumours; Neoplasms Details
Sym-015 Sym-015 Phase 2 Clinical Symphogen A/S Neoplasms; Carcinoma, Non-Small-Cell Lung Details
SPH-3348 SPH-3348; SPH3348; I-020 Phase 1 Clinical Shanghai Pharmaceuticals Holding Co Ltd Solid tumours; Neoplasms Details
GB-263 GB-263; GB-263T Phase 2 Clinical Genor Biopharma Co Ltd Solid tumours; Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Fosgonimeton ATH-1017; NDX-1017 Phase 3 Clinical M3 Biotechnology Alzheimer Disease; Lewy Body Disease Details
ABBV-400 ABBV-400 Phase 1 Clinical Abbvie Inc Solid tumours; Biliary Tract Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details
RC-108 RC-108; RC108 Phase 2 Clinical RemeGen Co Ltd Solid tumours; Digestive System Neoplasms; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms Details
SHR-A1403 SHR-A1403 Phase 1 Clinical Jiangsu Hengrui Medicine Co Ltd Solid tumours Details
Boxitinib Hydrochloride Phase 1 Clinical Hec Pharm Co Ltd Stomach Neoplasms; Carcinoma, Renal Cell; Breast Neoplasms; Glioma; Lung Neoplasms Details
CM-118 CM-118 Phase 1 Clinical Xcovery Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Recombinant plasmid-hepatocyte growth factor Pudk-HGF Phase 3 Clinical Wuhan Optical Valley Humanwell Biological Pharmaceutical Co Ltd, Academy Of Military Medical Sciences Ischemia; Peripheral Arterial Disease Details
FPI-2068 FPI-2068 Phase 1 Clinical Fusion Pharmaceuticals Inc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details
GST-HG161 GST-HG161 Phase 1 Clinical Wuxi Apptec Co Ltd, Fujian Cosunter Pharmaceutical Co Ltd Solid tumours; Neoplasms; Carcinoma, Hepatocellular Details
MYTX-011 MYTX-011 Phase 1 Clinical Mythic Therapeutics Inc Carcinoma, Non-Small-Cell Lung Details
BPI-9016 BPI-9016; BPI-9016M Phase 1 Clinical Betta Pharmaceuticals Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details
LM-061 LM-061 Phase 1 Clinical Shanghai Lixin Pharmaceutical Research and Development Co Ltd Solid tumours Details
Refanalin ANG-3777; BB-3; SNV-003 Phase 3 Clinical Vifor Pharma Ag, Angion Biomedica Corp Myocardial Infarction; Pneumonia; Coronavirus Disease 2019 (COVID-19); Delayed Graft Function; Acute Kidney Injury Details
TAVO-412 TAVO-412 Phase 1 Clinical Tavotek Biotherapeutics (Hong Kong) Ltd, Tuochuang Biotechnology (Jiangsu) Co Ltd Solid tumours; Neoplasms Details
Telisotuzumab vedotin ABT-399; ABBV-399 Phase 3 Clinical Abbvie Inc Solid tumours; Carcinoma, Non-Small-Cell Lung Details

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