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Your Position: Home > Claudin-18.1

Claudin-18.1

Brief Information

Name:Claudin-18 splice variant 2
Target Synonym:UNQ778/PRO1572,CLDN18,Claudin 18,Surfactant Associated Protein J,Surfactant, Pulmonary Associated Protein J,Surfactant Associated 5,Claudin-18,SFTA5,SFTPJ,Claudin 18.2,CLDN18.2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:62
Lastest Research Phase:NDA/BLA

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By Product Category:
By Species:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
CL1-H52P3 Human Human Claudin-18.1 Full Length Protein (VLP)
CL1-H5588 Human Human Claudin-18.1 Protein, His,Twin-Strep Tag (Detergent)
CL1-H5588-structure
ACRO Quality

Part of Bioactivity data

CL1-H52P3-SPR
 Claudin-18.1 ELISA

Immobilized Human Claudin-18.1 Full Length Protein (VLP) (Cat. No. CL1-H52P3) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Human Cludin18.1 antibody, Mouse IgG with a linear range of 2-78 ng/mL (QC tested).

Synonym Name

Claudin-18.1,CLDN18,Claudin-18

Background

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
LM-102 LM-102 Phase 1 Clinical LaNova Medicines Ltd Solid tumours; Biliary Tract Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms Details
IBI-345 IBI-345 Innovent Biologics(Suzhou) Co Ltd Details
Recombinant humanized anti-Claudin 18.2 monoclonal antibody (CARsgen) AB-011 Phase 2 Clinical Kaixing Life Technology (Shanghai) Co Ltd, Carsgen Biomedicine (Shanghai) Co Ltd Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms Details
CMG901 CMG-901; CMG901 Phase 1 Clinical Keymed Biosciences Co Ltd Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms; Adenocarcinoma Details
SHR-A-1904 SHR-A-1904; SHR-A1904 Phase 2 Clinical Shanghai Hengrui Pharmaceutical Co Ltd Solid tumours; Pancreatic Neoplasms Details
QLS-31905 QLS-31905 Phase 2 Clinical Qilu Pharmaceutical Co Ltd Solid tumours; Neoplasms Details
RD-07 RD-07 Phase 1 Clinical Peking University Solid tumours Details
NBL-015 NBL-015 Phase 1 Clinical Shanghai Xinshi Biological Medicine Co Ltd Solid tumours; Stomach Neoplasms; Pancreatic Neoplasms Details
BC-008 BC-008 Phase 1 Clinical Dragonboat Biopharmaceutical Solid tumours; Neoplasms Details
CLDN18.2-TAC T cells Therapy CLDN-18.2-TAC T cells; CLDN18.2-TAC T cells Phase 2 Clinical Triumvira Immunologics Inc Solid tumours; Stomach Neoplasms; Neoplasm Metastasis Details
DR-30303 DR30303 Phase 1 Clinical Zhejiang Doer Biologics Corp Solid tumours Details
SYSA-1801 SYSA-1801; SYSA1801; CPO-102; EO-3021 Phase 1 Clinical Jushi Biopharmaceutical Co Ltd Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms; Neoplasms; Digestive System Neoplasms; Gastrointestinal Neoplasms Details
HBM-7022 HBM-7022; AZD-5863 Phase 2 Clinical Harbour Biomed Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Neoplasms; Digestive System Neoplasms; Esophageal adenocarcinoma; Carcinoma, Pancreatic Ductal; Gastrointestinal Neoplasms Details
IBI-389 IBI-389 Phase 1 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours; Neoplasms Details
LCAR-C18S CAR-T cell therapy LB-1908; LCAR-C18S; LCAR-C-18-S Phase 1 Clinical Nanjing Legend Biotechnology Co Ltd Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Digestive System Neoplasms; Gastrointestinal Neoplasms Details
Gresonitamab AMG-910 Phase 1 Clinical Amgen Inc Esophageal Neoplasms; Stomach Neoplasms; Adenocarcinoma Details
SKB-315 SKB-315; SKB315 Phase 1 Clinical Sichuan Kelun-Biotech Biopharmaceutical Co Ltd Solid tumours Details
Recombinant humanized monoclonal antibody MIL93(Mabworks) MIL-93 Phase 2 Clinical Beijing Mabworks Biotech Co Ltd Solid tumours; Neoplasms Details
IBI-360 IBI-360 Phase 1 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours; Neoplasms Details
Q-1802 Q-1802 Phase 2 Clinical Qiyu Biotechnology (Shanghai) Co Ltd Solid tumours; Esophageal Neoplasms; Gastrointestinal Neoplasms Details
LB-1904 LB-1904 Phase 1 Clinical Nanjing Legend Biotechnology Co Ltd Stomach Neoplasms Details
KD-182 KD-182 Phase 2 Clinical Nanjing Kaedi Biotechnology Co Ltd Stomach Neoplasms; Carcinoma, Pancreatic Ductal Details
LB-4330 Bis-2; LB-4330 Phase 1 Clinical L&L Biopharma Co Ltd Solid tumours Details
Givastomig TJ-CD4B; ABL-111; TJ-CLDN4B; TJ-033721; TJ-CD4B/ABL111 Phase 1 Clinical I-Mab Biopharma Co Ltd Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Neoplasms; Esophageal adenocarcinoma; Neoplasm Metastasis Details
M-108 M108; M-108 Phase 3 Clinical FutureGen Biopharm (Beijing) Co Ltd Solid tumours; Esophageal Neoplasms; Stomach Neoplasms Details
68Ga-PMD22(Peking Union Medical College Hospital) Phase 1 Clinical Peking Union Medical College Hospital Gastrointestinal Neoplasms Details
CT-041 CT041 Phase 2 Clinical CARsgen Therapeutics Holdings Ltd Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Adenocarcinoma Details
CT-048 CT-048; KJ-C1807; KJ-C-1807 Phase 1 Clinical Carsgen Biomedicine (Shanghai) Co Ltd Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Adenocarcinoma Details
BC-007 (Dragonboat Biopharmaceutical) BC-007 Phase 1 Clinical Dragonboat Biopharmaceutical Solid tumours; Neoplasms Details
ASP-2138 ASP-2138 Phase 1 Clinical Astellas Pharma Global Development Inc, Xencor Inc Stomach Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms Details
SG-1906 SG-1906; SG1906 Phase 1 Clinical Hangzhou Sumgen Biotechnology Co Ltd Solid tumours; Neoplasms Details
LY-011(Shanghai Longyao) LY-011 Phase 1 Clinical Shanghai Longyao Biological Technology Co Ltd Stomach Neoplasms; Pancreatic Neoplasms Details
IMC-002(Suzhou Immunofoco) IMC-002 Phase 2 Clinical Suzhou Immunofoco Biotechnology Co Ltd Ovarian Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Digestive System Neoplasms; Adenocarcinoma Details
XNW-27011 XNW-27011 Phase 2 Clinical Suzhou Sinovent Pharmaceuticals Co Ltd Solid tumours Details
CLDN18.2 UCAR-T cell therapy CLDN18.2 UCAR-T Clinical Zhongshan City People'S Hospital, T-Maximum Pharmaceutical (Suzhou) Co Ltd Stomach Neoplasms Details
LM-302 LM-302; TPX-4589 Phase 2 Clinical Eli Lilly Trading (Shanghai) Co Ltd Solid tumours; Stomach Neoplasms; Pancreatic Neoplasms; Neoplasms; Gastrointestinal Neoplasms Details
HEC-016 HEC-016 Phase 1 Clinical People Hospital Of Luohu,Shenzhen Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms Details
IBI-343 IBI-343 Phase 1 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Neoplasms Details
BA-1105 BA-1105; BA1105 Phase 1 Clinical Shandong Boan Biotechnology Co Ltd Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms Details
BA-1301 BA-1301; BA1301 Phase 1 Clinical Shandong Boan Biotechnology Co Ltd Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms Details
AK-132 AK132; AK-132 Phase 1 Clinical Zhongshan Akeso Biopharma Co Ltd Solid tumours; Neoplasms Details
ATG-022 ATG-022 Phase 1 Clinical Antengene Corporation Co Ltd Solid tumours; Stomach Neoplasms; Neoplasms; Neoplasm Metastasis Details
AZD-6422 AZD6422; AZD-6422 Phase 1 Clinical Astrazeneca Plc Gastrointestinal Neoplasms Details
SPX-101 (Sparx Therapeutics) KY-71113; SX-001; KY71113; SPX-101 Phase 1 Clinical Sparx Therapeutics Inc, Kpc Pharmaceuticals Inc Solid tumours; Stomach Neoplasms Details
PM-3023 PM-3023 Phase 1 Clinical Biotheus Inc Solid tumours Details
SOT-102 SOT102; SO-N102; SOT-102 Phase 2 Clinical Sotio Biotech AG Stomach Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms; Digestive System Neoplasms; Gastrointestinal Neoplasms Details
124I-18B10 124-I-18-B-10; 124I-18B10 Clinical Transcenta Holding Ltd, Beijing Cancer Hospital Gastrointestinal Neoplasms Details
Osemitamab MSB-018; TST-001 Phase 3 Clinical Mabspace Biomedicine (Suzhou) Co Ltd, HJB (Hangzhou) Co Ltd Biliary Tract Neoplasms; Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Neoplasms; Pancreatic Neoplasms; Digestive System Neoplasms; Lung Neoplasms; Gallbladder Neoplasms; Gastrointestinal Neoplasms Details
TORL-2-307-ADC TORL-2-307-ADC Phase 1 Clinical Torl Biotherapeutics LLC Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Adenocarcinoma Details
TQB-2103 TQB2103; TQB-2103 Phase 1 Clinical Nanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical Group Neoplasms Details
PM-1032 PM1032; PM-1032 Phase 2 Clinical Biotheus Inc, Shanghai Genechem Co Ltd Neoplasms Details
KD-496 KD-496(4th); KD-496 Phase 1 Clinical Nanjing Kaedi Biotechnology Co Ltd Solid tumours; Stomach Neoplasms; Neoplasms; Pancreatic Neoplasms Details
PT-886 PT-886 Phase 1 Clinical Stomach Neoplasms; Pancreatic Neoplasms Details
JS-107 JS-107 Phase 1 Clinical Shanghai Junshi Biosciences Co Ltd Solid tumours; Pancreatic Neoplasms Details
RC-118 YH005 ADC; RC-118 Phase 2 Clinical RemeGen Co Ltd, Biocytogen Pharmaceuticals (Beijing) Co Ltd Solid tumours; Neoplasm Metastasis Details
BIO-008 BIO-008 Phase 1 Clinical Shijiazhuang Yiling Pharmaceutical Co Ltd Solid tumours Details
QL-1779 QL-1779; QL1779 Phase 1 Clinical Qilu Pharmaceutical Co Ltd Solid tumours Details
IM-92 IM-92 Phase 1 Clinical Beijing Immunochina Medical Science & Technology Co Ltd Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms Details
89Zr-NY005 89Zr-NY005 Clinical Wuxi No 4 People'S Hospital Solid tumours Details
ASKB-589 ASKB-589 Phase 3 Clinical Jiangsu Aosaikang Pharmaceutical Co Ltd Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Adenocarcinoma Details
HBM-1029 HBM-1029; HBM1029 Phase 1 Clinical Harbour Biomed Solid tumours; Stomach Neoplasms; Esophageal Neoplasms Details

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