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Your Position: Home > CCR8

CCR8

Brief Information

Name:C-C chemokine receptor type 8
Target Synonym:Chemokine (C-C) Receptor 8,CC Chemokine Receptor 8,CDw198 Antigen,C-C CKR-8,CC-CKR-8,CCR-8,CMKBRL2,C-C Motif Chemokine Receptor 8,CC chemokine receptor CHEMR1,C-C chemokine receptor type 8,Chemokine (C-C Motif) Receptor 8,C-C Chemokine Receptor Type 8,CC Chemokine Receptor CHEMR1,Chemokine Receptor-Like 1,Chemokine (C-C) Receptor-Like 2,CC-Chemokine Receptor Chemr1,CD_antigen=CDw198,Chemokine receptor-like 1,CKRL1,CKR-L1,CMKBR8,GPRCY6,GPR-CY6,TER1,CDw198,CY6
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Phase 2 Clinical

Licensing

Project Name Modality Therapeutic Area Indications Stage Right Available
CCR8 Humanized Antibody Bispecific antibody Oncology/Cancer Solid Tumor Preclinical Global

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Cat. No. Species Product Description Structure Purity Feature
CC8-H52D7 Human Human CCR8 Protein, Flag,His Tag&Twin-Strep Tag (Nanodisc)
CC8-H52D6 Human Human CCR8 Protein, Flag,His Tag&Twin-Strep Tag (Detergent)
CHEK-ATP140 Human HEK293/Human CCR8 Stable Cell Line
CC8-H52P4 Human Human CCR8 Full Length Protein (VLP)
ACRO Quality

Part of Bioactivity data

CHEK-ATP140-Cell-based assay
CCR8 FACS

Expression analysis of human CCR8 on HEK293/Human CCR8 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human CCR8 Stable Cell Line or negative control cell using anti-human CCR8 antibody followed by staining with PE anti-human IgG antibody.

Protocol
CC8-H52D6-SPR
CCR8 SPR

Anti-CCR8 captured on Protein A Chip can bind Human CCR8 Protein, Flag,His Tag&Twin-Strep Tag (Cat. No. CC8-H52D6) with an affinity constant of 63.8 nM as determined in a SPR assay (in presence of DDM and CHS) (Biacore 8K) (Routinely tested).

Protocol
CC8-H52D6-ELISA
CCR8 ELISA

Immobilized Human CCR8 Protein, Flag,His Tag&Twin-Strep Tag (Cat. No. CC8-H52D6) at 0.5 μg/mL (100 μL/well) can bind Anti-CCR8 Antibody, Human IgG1 with a linear range of 0.2-6 ng/mL (QC tested).

Protocol

Synonym Name

CC chemokine receptor 8,CD198,,ChemR1,CKRL1,CKR-L1,CKRL1,CY6,GPRCL1,GPRCY6,GPR-CY6,TER-1

Background

This entry represents CC chemokine receptor 8 (CCR8), which it is expressed predominantly in lymphoid tissues and has also been found in glomerular podocytes and human umbilical vein endothelial cells (HUVECs). CCR8 is associated with Th2 lymphocytes, which are critical for allergy, and has a role in lymphocyte activation, migration, proliferation and differentiation and in allergic diseases. CCR8 binds to CCL1 (also known as I-309) and to CCL16 (also known as liver expressed chemokine). It also exhibits a high affinity for three chemokines of viral origin: vMIP-I, vMIP-II and vMCC-I.

Clinical and Translational Updates

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