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PTK7

Brief Information

Name:Protein-tyrosine kinase 7
Target Synonym:Colon carcinoma kinase 4,Inactive tyrosine-protein kinase 7,Tyrosine-protein kinase-like 7,CCK-4,PTK7,Protein Tyrosine Kinase 7 (Inactive),Pseudo Tyrosine Kinase Receptor 7,PTK7 Protein Tyrosine Kinase 7,CCK4,Protein-Tyrosine Kinase 7,Protein Tyrosine Kinase 7
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

CHEK-ATP186-Cell-based assay
 PTK7 FACS

Expression analysis of human PTK7 on HEK293/Human PTK7 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human PTK7 Stable Cell Line or negative control cell using anti-human PTK7 antibody followed by fixation with 4% paraformaldehyde, and then stained with PE anti-human IgG Fc antibody.

PT7-C52H3-ELISA
 PTK7 ELISA

Immobilized Cynomolgus / Rhesus macaque PTK7, His Tag (Cat. No. PT7-C52H3) at 1 μg/mL (100 μL/well) can bind Cofetuzumab Pelidotin with a linear range of 0.06-2 ng/mL (Routinely tested).

PT7-M5256-MALS-HPLC
PTK7 MALS images

The purity of Mouse PTK7 Protein, Fc Tag (Cat. No. PT7-M5256) is more than 90% and the molecular weight of this protein is around 240-270 kDa verified by SEC-MALS.

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Synonym Name

PTK7,CCK4,CCK-4,Tyrosine-protein kinase-like 7,Protein-tyrosine kinase 7,Protein-tyrosine kinase 7

Background

PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Cofetuzumab Pelidotin PF-06647020; PF-6647020; PTK7-ADC; PF-06523435; PF-7020; hu-24; ABBV-647; Anti-PTK7 ADC; h6M24-vc0101 Phase 1 Clinical Stemcentrx Inc, Abbvie Inc Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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