Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
user
  1. Dashboard
  2. My Profile
  3. My Address
  4. My Orders
  5. Acro Membership
Login Register
Promotion
Recombinant Proteins ClearClear history
Recombinant Proteins CloseClose
Browse Products By Molecule Name a-zA-Z
TL1A Hot |GMP Cytokines Hot |Streptavidin（SA） Hot |Claudin 18.2 |Cadherin-17 
0
There is no goods in the shopping cart !
My Cart|Secure Checkout
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Osteoprotegerin

Osteoprotegerin

Brief Information

Name:Tumor necrosis factor ligand superfamily member 11
Target Synonym:Osteoclast differentiation factor,TRANCE,TNFSF11,TNF-related activation-induced cytokine,Tumor necrosis factor ligand superfamily member 11,CD254,TNF Superfamily Member 11,Osteoprotegerin Ligand,Receptor Activator Of Nuclear Factor Kappa B Ligand,Tumor Necrosis Factor Superfamily Member 11,ODF,RANKL,OPGL,CD254 Antigen,HRANKL2,TNLG6B,OPTB2,SOdf,RANK Ligand,Tumor Necrosis Factor (Ligand) Superfamily, Member 11,Receptor Activator Of Nuclear Factor Kappa-B Ligand,Tumor Necrosis Factor Ligand 6B
Number of Launched Drugs:7
Number of Drugs in Clinical Trials:27
Lastest Research Phase:Approved

Product ListCompare or Buy

Product> Filter Results
By Product Status:
By Product Category:
By Species:
By Tag:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
TNB-H5220 Human Human Osteoprotegerin / TNFRSF11B Protein, His Tag
TNB-H5220-structure
TNB-H5220-sds
TNB-H5259 Human Human Osteoprotegerin / TNFRSF11B Protein, Fc Tag
TNB-H5259-structure
TNB-H5259-sds
ACRO Quality

Part of Bioactivity data

TNB-H5220-BLI
Osteoprotegerin BLI

Loaded Human Osteoprotegerin, His Tag (Cat. No. TNB-H5220) on HIS1K Biosensor, can bind Human TRAIL with an affinity constant of 0.831 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
TNB-H5259-BLI
Osteoprotegerin BLI

Loaded Human TRAIL, His Tag on HIS1K Biosensor, can bind Human Osteoprotegerin, Fc Tag (Cat. No. TNB-H5259) with an affinity constant of 1.65 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

TNFRSF11B,OCIF,OPG,Osteoprotegerin

Background

Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Clinical and Translational Updates

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Email
Email
order@acrobiosystems.com
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA
linkedin twitter facebook youtube

Leave a message

Copyright © 2017 ACROBiosystems. All Rights Reserved
|Related Links|Privacy Policy|Terms and Conditions|Legal|Sitemap