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Your Position: Home > Protein > Lymphotoxin alpha1/beta2 > LY2-H5263

Human Lymphotoxin alpha1/beta2 Protein, Fc Tag (MALS verified)

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  • Source
    Human Lymphotoxin alpha1/beta2 Protein, Fc Tag(LY2-H5263) is expressed from human 293 cells (HEK293). It contains AA Lys 62 - Leu 205 (alpha1) & Asp 82 - Gly 244 (beta2) (Accession # P01374 (alpha1) & Q06643 (beta2)).
    Predicted N-terminus: Pro
  • Molecular Characterization

    This protein carries a human IgG1 Fc tag at the N-terminus.

    The protein has a calculated MW of 78.3 kDa. The protein migrates as 65-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Lymphotoxin alpha1/beta2 SDS-PAGE

Human Lymphotoxin alpha1/beta2 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS
Lymphotoxin alpha1/beta2 MALS images

The purity of Human Lymphotoxin alpha1/beta2 Protein, Fc Tag (Cat. No. LY2-H5263) is more than 90% and the molecular weight of this protein is around 150-190 kDa verified by SEC-MALS.

Bioactivity-ELISA
 Lymphotoxin alpha1/beta2 ELISA

Immobilized Human Lymphotoxin alpha1/beta2 Protein, Fc Tag (Cat. No. LY2-H5263) at 5 μg/mL (100 μL/well) can bind Biotinylated Human LTBR, His,Avitag (Cat. No. LTR-H82E9) with a linear range of 0.1-10 ng/mL (QC tested).

  • Background
    Lymphotoxin alpha1/bate2 (LT α1/β1) are members of the tumor necrosis factor (TNF) superfamily, and plays a pivotal role in the establishment and regulation of the immune system. The predominant form on the lymphocyte surface is the lymphotoxin alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin beta receptor (LTβR). The minor complex is lymphotoxin alpha 2/beta 1. Lymphotoxin alpha mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Lymphotoxin beta is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue.
  • Clinical and Translational Updates

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Price(USD) : $350.00

Price(USD) : $2310.00

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