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Your Position: Home > Antibody > Spike RBD > SPD-M541

Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (10B1A5) (BA.2&BA.4&BA.5/Omicron Specific) (MALS verified)

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  • Source
    Anti-SARS-CoV-2 Spike RBD Antibody, Human IgG1 (10B1A5) (BA.2&BA.4&BA.5/Omicron Specific) is isolated from a Spike RBD infected Mouse and is recombinantly produced from human 293 cells (HEK293)
  • Isotype
    Human IgG1/kappa
  • Specificity
    This product is a specific antibody specifically reacts with Spike RBD.
  • Application
    ELISA
  • Purity

    >95% as determined by SDS-PAGE.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Spike RBD SDS-PAGE

Anti-SARS-CoV-2 Spike RBD Antibody, Human IgG1 (10B1A5) (BA.2&BA.4&BA.5/Omicron Specific) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Spike RBD MALS images

The purity of Anti-SARS-CoV-2 Spike RBD Antibody, Human IgG1 (10B1A5) (BA.2&BA.4&BA.5/Omicron Specific) (Cat. No. SPD-M541) is more than 0.95 and the molecular weight of this protein is around 135-155 kDa verified by SEC-MALS.

Bioactivity-Elisa
 Spike RBD ELISA

Immobilized SARS-CoV-2 Spike RBD, His Tag (BA.2/Omicron) (Cat. No. SPD-C522g) at 1 μg/mL (100 μL/well) can bind Anti-SARS-CoV-2 Spike RBD Antibody, Human IgG1 (10B1A5) (BA.2&BA.4&BA.5/Omicron Specific) (Cat. No. SPD-M541) with a linear range of 0.5-63 ng/mL (QC tested).

 Spike RBD ELISA

Immobilized SARS-CoV-2 Spike RBD, His Tag (BA.2.12.1/Omicron) (Cat. No. SPD-C522q) at 1 μg/mL (100 μL/well) can bind Anti-SARS-CoV-2 Spike RBD Antibody, Human IgG1 (10B1A5) (BA.2&BA.4&BA.5/Omicron Specific) (Cat. No. SPD-M541) with a linear range of 0.2-16 ng/mL (QC tested).

 Spike RBD ELISA

Immobilized SARS-CoV-2 Spike RBD, His Tag (BA.4&BA.5/Omicron) (Cat. No. SPD-C522r) at 1 μg/mL (100 μL/well) can bind Anti-SARS-CoV-2 Spike RBD Antibody, Human IgG1 (10B1A5) (BA.2&BA.4&BA.5/Omicron Specific) (Cat. No. SPD-M541) with a linear range of 0.5-16 ng/mL (QC tested).

Bioactivity-SPR
 Spike RBD SPR

Anti-SARS-CoV-2 Spike RBD Antibody, Human IgG1 (10B1A5) (BA.2&BA.4&BA.5/Omicron Specific) (Cat. No. SPD-M541) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind SARS-CoV-2 Spike RBD, His Tag (BA.4&BA.5/Omicron) (Cat. No. SPD-C522r) with an affinity constant of 15.5 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

 Spike RBD SPR

Anti-SARS-CoV-2 Spike RBD Antibody, Human IgG1 (10B1A5) (BA.2&BA.4&BA.5/Omicron Specific) (Cat. No. SPD-M541) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind SARS-CoV-2 Spike RBD, His Tag (BA.2.12.1/Omicron) (Cat. No. SPD-C522q) with an affinity constant of 11.9 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

 Spike RBD SPR

Anti-SARS-CoV-2 Spike RBD Antibody, Human IgG1 (10B1A5) (BA.2&BA.4&BA.5/Omicron Specific) (Cat. No. SPD-M541) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind SARS-CoV-2 Spike RBD, His Tag (BA.2/Omicron) (Cat. No. SPD-C522g) with an affinity constant of 11.1 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

  • Background
    Its been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
  • Clinical and Translational Updates

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ETD of in-stock products: 2 business days

Price(USD) : $350.00

Price(USD) : $2310.00

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