Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
user
  1. Dashboard
  2. My Profile
  3. My Address
  4. My Orders
  5. Acro Membership
Login Register
Promotion
Recombinant Proteins ClearClear history
Recombinant Proteins CloseClose
Browse Products By Molecule Name a-zA-Z
TL1A Hot |GMP Cytokines Hot |Streptavidin（SA） Hot |Claudin 18.2 |Cadherin-17 
0
There is no goods in the shopping cart !
My Cart|Secure Checkout
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Siglec-15

Siglec-15

Brief Information

Name:Sialic acid-binding Ig-like lectin 15
Target Synonym:SIGLEC15,Sialic Acid Binding Ig Like Lectin 15,CD33 Antigen-Like 3,CD33L3,Sialic Acid-Binding Ig-Like Lectin 15,SIGLEC-15,HsT1361,CD33 Molecule-Like 3,Sialic Acid Binding Ig-Like Lectin 15
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

Product ListCompare or Buy

Product> Filter Results
By Product Status:
By Product Category:
By Species:
By Tag:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
SG5-H5254 Human Human Siglec-15 / CD33L3 Protein, Mouse IgG2a Fc Tag (MALS verified)
SG5-H5254-structure
SG5-H5254-sds
SG5-C5253 Cynomolgus Cynomolgus Siglec-15 / CD33L3 Protein, Fc Tag
SG5-C5253-structure
SG5-C5253-sds
SG5-H82F5 Human Biotinylated Human Siglec-15 / CD33L3 Protein, Fc,Avitag™
SG5-H82F5-structure
SG5-H82F5-sds
SG5-H82E9 Human Biotinylated Human Siglec-15 / CD33L3 Protein, His,Avitag™ (recommended for biopanning)
SG5-H82E9-structure
SG5-H82E9-sds
SG5-M52H7 Mouse Mouse Siglec-15 / CD33L3 Protein, His Tag
SG5-M52H7-structure
SG5-M52H7-sds
SG5-C52H6 Cynomolgus Cynomolgus Siglec-15 / CD33L3 Protein, His Tag
SG5-C52H6-structure
SG5-C52H6-sds
SG5-H5253 Human Human Siglec-15 / CD33L3 Protein, Fc Tag
SG5-H5253-structure
SG5-H5253-sds
SG5-H52H3 Human Human Siglec-15 / CD33L3 Protein, His Tag (MALS verified)
SG5-H52H3-structure
SG5-H52H3-sds
ACRO Quality

Part of Bioactivity data

SG5-H82F5-Cell-based assay
Siglec-15 CELL

Biotinylated Human Siglec-15, Fc,Avitag (Cat. No. SG5-H82F5) inhibits Anti-CD3-induced proliferation of PBMC. The ED50 for this effect is 0.48-0.57 μg/mL (Routinely tested).

Protocol
SG5-H5253-Cell-based assay
Siglec-15 CELL

Human Siglec-15, Fc Tag (Cat. No. SG5-H5253) inhibits Anti-CD3-induced proliferation of PBMC. The ED50 for this effect is 0.46-0.54 μg/mL (Routinely tested).

Protocol
SG5-H5253-SPR
Siglec-15 SPR

Immobilized Neu5Ac(a2-6)GalNAc-PAA-biotin on SA Chip can bind Human Siglec-15, Fc Tag (Cat. No. SG5-H5253) with an affinity constant of 4.49 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
SG5-C5253-BLI
Siglec-15 BLI

Loaded Cynomolgus Siglec-15, Fc Tag (Cat. No. SG5-C5253) on ProteinA Biosensor, can bind Neu5Ac(a2-6)GalNAc-PAA-biotin with an affinity constant of 0.62 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Customer Reviews

Synonym Name

CD33 antigen-like 3,SIGLEC-15,CD33L3,sialic acid-binding Ig-like lectin 15,Siglec15,Siglec-15

Background

Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
DS-1501 DS-1501 Phase 1 Clinical Daiichi Sankyo Co Ltd Osteoporosis Details
NC-318 NC-318; 5G-12 Phase 2 Clinical Yale School Of Medicine Solid tumours; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Breast Neoplasms; Lung Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma Details
PYX-106 PYX-106; BSI-060T Phase 1 Clinical Solid tumours; Neoplasm Metastasis Details

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Email
Email
order@acrobiosystems.com
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA
linkedin twitter facebook youtube

Leave a message

Copyright © 2017 ACROBiosystems. All Rights Reserved
|Related Links|Privacy Policy|Terms and Conditions|Legal|Sitemap