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Your Position: Home > M-CSF

M-CSF

Brief Information

Name:Macrophage Colony Stimulating Factor 1
Target Synonym:M-CSF,Macrophage colony-stimulating factor 1,CSF-1,CSF1,Colony Stimulating Factor 1,Colony Stimulating Factor 1 (Macrophage),Macrophage Colony Stimulating Factor 1,Lanimostim,MCSF,Macrophage Colony-Stimulating Factor,MGC31930
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
MCF-H82E6 Human Biotinylated Human M-CSF / CSF-1 Protein, His,Avitag™
MCF-H82E6-structure
MCF-H82E6-sds
MCF-H5247 Human Human M-CSF / CSF-1 Protein, His Tag
MCF-H5247-structure
MCF-H5247-sds

Part of Bioactivity data

MCF-H82E6-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) stimulates proliferation of RAW264.7 cells. The EC50 for this effect is 6.20-7.15 ng/mL (Routinely tested).

Protocol
MCF-H5247-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human M-CSF, His Tag (Cat. No. MCF-H5247) stimulates proliferation of RAW264.7 cells. The EC50 for this effect is 4.40-5.27 ng/mL (Routinely tested).

Protocol
MCF-H82E6-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) immobilized on SA Chip can bind Human M-CSF R, His Tag (Cat. No. CSR-H5228) with an affinity constant of 0.309 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
MCF-H5247-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human M-CSF, His Tag (Cat. No. MCF-H5247) captured on CM5 Chip via anti-His antibody can bind Human M-CSF R, Fc Tag, low endotoxin (Cat. No. CSR-H5258) with an affinity constant of 1.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

M-CSF,CSF-1,Lanimostim

Background

The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which influences hematopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. It is one of the three experimentally described colony-stimulating factors. M-CSF binds to the colony stimulating factor 1 receptor. Macrophage colony-stimulating factor has been shown to interact with PIK3R2. M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. Locally produced M-CSF in the vessel wall contributes to the development and progression of atherosclerosis.

Clinical and Translational Updates

Related Molecule

M-CSF R

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Lacnotuzumab MCS-110 Phase 2 Clinical Novartis Pharma Ag Giant Cell Tumor of Tendon Sheath; Bone metastases; Synovitis, Pigmented Villonodular; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Giant Cell Tumors; Breast Neoplasms; Prostatic Neoplasms; Endometrial Neoplasms; Melanoma Details
PD-360324 PD-360324; PD-0360324 Phase 2 Clinical Pfizer Pharmaceuticals Ltd (China) Neoplasms; Lupus Erythematosus, Cutaneous; Sarcoidosis, Pulmonary Details

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