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Your Position: Home > IFN-gamma

IFN-gamma

Brief Information

Name:Interferon gamma
Target Synonym:Immune interferon,Interferon gamma,IFNG,IFN-Gamma,IFG,IFI,Interferon-gamma
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Approved

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ACRO Quality

Part of Bioactivity data

GMP-IFGH24-Cell-based assay
 IFN-gamma CELL

GMP Human IFN-gamma Protein (Cat. No. GMP-IFGH24) inhibits the proliferation of HT-29 cells. The specific activity of GMP Human IFN-gamma Protein is>2.0*10^7 IU/mg, which is calibrated against human interferon gamma Standard (NIBSC code: 87/586) (QC tested).

IFG-H4211-Cell-based assay
 IFN-gamma CELL

Human IFN-gamma, premium grade (Cat. No. IFG-H4211) inhibits the proliferation of HT-29 cells. The specific activity of Human IFN-gamma, premium grade is>2.00*10^7 IU/mg, which is calibrated against human interferon gamma Standard (NIBSC code: 87/586) (QC tested).

IFN-BS138-SPR
 IFN-gamma SPR

Biotinylated Monoclonal Anti-IFNγ Antibody, Mouse IgG1 (13E6H6) (Cat. No. IFN-BS138) captured on CM5 chip via anti-mouse antibodies surface can bind Human IFN-gamma, premium grade (Cat. No. IFG-H4211) with an affinity constant of 1.28 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

IFN-S120-SPR
 IFN-gamma SPR

Monoclonal Anti-IFNγ antibody, Mouse IgG2a (8C5F8) (Cat. No. IFN-S120) captured on CM5 chip via anti-mouse antibodies surface can bind Human IFN-gamma, premium grade (Cat. No. IFG-H4211) with an affinity constant of 0.933 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Synonym Name

Interferon-gamma ,Interferon-γ

Background

Interferon-gamma (IFN-γ/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs. IFN-gamma has been used in a wide variety of clinical indications. Interferon-gamma (IFNgamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Emapalumab NI-0501 Approved Novimmune Sa Gamifant United States Lymphohistiocytosis, Hemophagocytic Novimmune Sa 2018-11-20 Macrophage Activation Syndrome; Still's Disease, Adult-Onset; Rare Diseases; Immune System Diseases; Arthritis, Juvenile; Lupus Erythematosus, Systemic; Lymphohistiocytosis, Hemophagocytic Details
Thalidomide NSC-66847; NSC-527179; K-17; VP-02; FPF-300; FPF300 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Mainland China Leprosy, Lepromatous; Multiple Myeloma Changzhou Pharmaceutical Factory 1982-01-01 Lymphoma, Mantle-Cell; Leprosy, Lepromatous; Colorectal Neoplasms; Neuroectodermal Tumors, Primitive; Prostatitis; Primary Myelofibrosis; Adenocarcinoma, Clear Cell; Lymphoma, Follicular; Carcinoma, Adenosquamous; Cholangitis, Sclerosing; Osteosarcoma; Endometrial Neoplasms; Xerostomia; Gastrointestinal Hemorrhage; Sarcoma, Ewing; HIV Wasting Syndrome; Pancreatitis, Chronic; Arachnoiditis; Retinoblastoma; Erythema Nodosum; Prostatic Neoplasms; Drug Resistant Epilepsy; Leukemia, Lymphocytic, Chronic, B-Cell; Vascular Malformations; Myelodysplastic-Myeloproliferative Diseases; Stomatitis; Burning Mouth Syndrome; Mycobacterium avium-intracellulare Infection; Amyotrophic Lateral Sclerosis; Neoplasm Metastasis; Carcinoma, Hepatocellular; Melanoma; Sarcoma; Angiodysplasia; Lymphoma, Non-Hodgkin; Appendiceal Neoplasms; Pelvic Pain; Waldenstrom Macroglobulinemia; Glioma; Uterine Neoplasms; Anemia, Sideroblastic; Lung Neoplasms; Mycobacterium Infections; Lupus Erythematosus, Discoid; Anemia, Refractory, with Excess of Details
Cadi-05 Cadi-05 Approved National Institute Of Allergy And Infectious Diseases (Niaid) Immuvac, Leprovac, Mycidac-C India Carcinoma, Non-Small-Cell Lung; Leprosy null 1998-01-01 Leprosy; Carcinoma, Non-Small-Cell Lung Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PDS-0101 PDS-0101B; PDS-0101C; PDS-0101; PDS-0101A; PDS-101 Phase 2 Clinical Pds Biotechnology Corporation, Merck Serono Head and Neck Neoplasms; Anus Neoplasms; Papillomavirus Infections; Vulvar Neoplasms; Oropharyngeal Neoplasms; Carcinoma, Squamous Cell; Uterine Cervical Neoplasms Details
EI-001 EI-001 Phase 1 Clinical Elixiron Immunotherapeutics Inc Vitiligo Details
KIO-100 PP-001; KIO-101; KIO-100 Phase 2 Clinical 4sc Ag Dry Eye Syndromes; Uveitis; Xerophthalmia; Keratoconjunctivitis Details
IFN-gamma-secreting HAdV antigen specific T cells (Case Comprehensive Cancer Center) Phase 1 Clinical Case Comprehensive Cancer Center Hematopoietic stem cell transplantation (HSCT) Details
Recombinant human interferon gamma adenovirus injection (Guangzhou Dabo Biological Products) Phase 1 Clinical Guangzhou Dabo Biological Products Co Ltd Liver Neoplasms; Nasopharyngeal Neoplasms; Prostatic Neoplasms, Castration-Resistant Details
SP-002 SP-002; ASN-002; TG-1042 Phase 2 Clinical Transgene Sa Solid tumours; Lymphoma, B-Cell; Carcinoma, Basal Cell; Skin Neoplasms; Basal Cell Nevus Syndrome; Melanoma Details
OCH-NCNP1 OCH-NCNP1 Phase 2 Clinical Keio University Multiple Sclerosis; Crohn Disease Details
Tadekinig alfa (AB2 Bio) Phase 3 Clinical Ab2 Bio Ltd Macrophage Activation Syndrome; Cytokine Release Syndrome; Lymphohistiocytosis, Hemophagocytic Details
YH-32367 ABL105; YH-32367 Phase 2 Clinical Abl Bio Inc Solid tumours; Stomach Neoplasms; Breast Neoplasms Details

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