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5e5 of anti-PSMA CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human PSMA, His Tag (Cat. No. PSA-HP2Q3) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).
2e5 of PSMA-CAR-293 cells transfected with anti-PSMA-scFv were stained with 100 μL of 1 μg/mL of Human PSMA, Fc Tag, premium grade (Cat. No. PSA-H5264) and negative control protein respectively, washed and then followed by PE anti-human IgG Fc antibody and analyzed with FACS (Routiney tested).
Immobilized Monoclonal Anti-Human PSMA Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind Biotinylated Cynomolgus PSMA Protein, His,Avitag (Cat. No. PSA-C82Q6) with a linear range of 0.5-16 ng/mL (QC tested).
The purity of Biotinylated Mouse PSMA Protein, Fc,Avitag (Cat. No. PSA-M82F3) is more than 85% and the molecular weight of this protein is around 230-260 kDa verified by SEC-MALS.
| Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
|---|---|---|---|---|---|---|---|---|---|---|
| Capromab pendetide | lndium-CYT-356; Indium-111-CYT-356; CYT-356; 111In CYT-356 | Approved | Eusa Pharma | ProstaScint | United States | Prostatic Neoplasms | Cytogen Corp | 1996-10-28 | Prostatic Neoplasms | Details |
| Piflufolastat F 18 | Approved | Johns Hopkins University | Pylarify, Pylclari | United States | Prostatic Neoplasms | Progenics Pharmaceuticals Inc | 2021-05-26 | Carcinoma, Renal Cell; Pancreatic Neoplasms; Prostatic Neoplasms; Breast Neoplasms; Genital Neoplasms, Female; Diagnostic agents; Adenocarcinoma; Carcinoma, Hepatocellular; Neoplasm Metastasis | Details | |
| Ga-68 PSMA-11 | Ga-68-PSMA-11; Ga-68-PSMA; 68Ga-HBED-CC-PSMA11; AAA517; AAA-517 | Approved | Radiomedix Inc | Gallium Ga 68 Psma-11, Illuccix, ILLUCCIX, Locametz | United States | Prostatic Neoplasms | Telix Pharmaceuticals Ltd, University Of California, Los Angeles | 2020-12-01 | Neoplasm Recurrence, Local; Solid tumours; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms; Prostatic Neoplasms; Breast Neoplasms; Diagnostic agents; Neoplasm Metastasis; Carcinoma, Hepatocellular | Details |
| Lutetium (177Lu) vipivotide tetraxetan | Lutetium-177-PSMA-617; PSMA-617-[177Lu]; 177-Lu-PSMA-617; AAA-617; Lu-177- RLT | Approved | Radiomedix Inc | PLUVICTO | United States | Prostatic Neoplasms, Castration-Resistant | Novartis Pharmaceuticals Corp | 2022-03-23 | Carcinoma, Verrucous; Prostatic Neoplasms, Castration-Resistant; Carcinoma, Adenoid Cystic; Prostatic Neoplasms; Carcinoma, Squamous Cell; Neoplasm Metastasis | Details |
| Flotufolastat F-18 | Fluorine-18 rhPSMA; rhPSMA-7.3 (18F); 18F-rhPSMA-7.3; (18F)-rhPSMA-7.3; 18FrhPSMA-7.3; F-18-rhPSMA-7.3 | Approved | Blue Earth Diagnostics Inc, Technical University Munich | POSLUMA | United States | Prostatic Neoplasms | Blue Earth Diagnostics Ltd | 2023-05-25 | Prostatic Neoplasms; Contrast agents | Details |
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| 18F-PSMA-1007 | 18F-PSMA-1007 | Phase 3 Clinical | Deutsches Krebsforschungszentrum | Neoplasms; Prostatic Neoplasms | Details |
| Gallium-68 PSMA-617 | 225 Ac-PSMA-617; 68Ga-PSMA-617; 68Ga-DKFZ-617; 68Ga-DKFZ-PSMA -617; Gallium-68-PSMA-617; PSMA-617-[68Ga]; 68Ga-DOTA-PSMA-DKFZ -617 | Phase 3 Clinical | Peking Union Medical College Hospital | Carcinoma, Adenoid Cystic; Prostatic Neoplasms | Details |
| Fluorine-18-CTT-1057 | CTT-1057; 18F-CTT1057; CTT-1057-18F; CTT-1057-F-18 | Phase 3 Clinical | Washington University, Cancer Targeted Technology Llc | Recurrence; Carcinoma, Renal Cell; Prostatic Neoplasms | Details |
| ITM-24D | ITM-24D; 68Ga-PSMA-TTM | Phase 3 Clinical | ITM Isotope Technologies Munich SE | Prostatic Neoplasms | Details |
| 18F vipivotide tetraxetan | 18F-PSMA-617; Al18F-PSMA-617 | Phase 3 Clinical | Peking Union Medical College Hospital | Prostatic Neoplasms | Details |
| 64Cu-PSMA I&T | Copper Cu 64 PSMA I&T; Cu-64-PSMA-I&T; 64-Copper-PSMA-I&T; Copper-64-prostate specific membrane antigen I&T | Phase 3 Clinical | Curium Us Llc | Prostatic Neoplasms | Details |
| Thretide[18F] | Phase 3 Clinical | Shanghai Lannacheng Biotechnology Co Ltd | Neoplasms; Prostatic Neoplasms; Diagnostic agents | Details | |
| 64Cu-SAR-bisPSMA (Clarity Pharmaceuticals) | Phase 3 Clinical | Clarity Pharmaceuticals Ltd | Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details | |
| 177Lu-DOTA-rosopatamb | 177Lu-DOTA-TLX591-CHO; TLX591 | Phase 3 Clinical | Telix Pharmaceuticals Ltd | Prostatic Neoplasms | Details |
| [Lu177]-PNT-2002 | PNT-2002 | Phase 3 Clinical | Carcinoma, Adenoid Cystic; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details | |
| Lutetium-177-PSMA-I&T | Phase 2 Clinical | Radboud University Nijmegen | Salivary Gland Neoplasms; Carcinoma, Adenoid Cystic; Prostatic Neoplasms | Details | |
| 68Ga-PSMA-R2 (Advanced Accelerator Applications SA) | Phase 2 Clinical | Advanced Accelerator Applications Sa | Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details | |
| 177Lu-PSMA-R2 | 177Lu-PSMA-R2; 177Lu-PSMA-SR6; AAA-602 | Phase 2 Clinical | Advanced Accelerator Applications Sa | Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details |
| 89Zr-DFO-huJ591 | Zr89-J591; 89Zr-DFO-J591; 89Zr-DFO-huJ591 | Phase 2 Clinical | Memorial Sloan Kettering Cancer Center | Prostatic Neoplasms | Details |
| Nezastomig | REGN-5678 | Phase 2 Clinical | Regeneron Pharmaceuticals Inc | Carcinoma, Renal Cell; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details |
| 225Ac-J591 | 225Ac-DOTA-J591; 225Ac-J591; CONV 01-α | Phase 2 Clinical | Cornell University | Prostatic Neoplasms | Details |
| ATL-101 | MLN-591RL; ATL-101; huJ-591; MLN-591; J-591; Lu-177-J591; 177Lu-J591; 90Y-J591; muJ-591 | Phase 2 Clinical | Weill Medical College of Cornell University | Ovarian Neoplasms; Head and Neck Neoplasms; Kidney Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Glioma; Carcinoma, Non-Small-Cell Lung | Details |
| [131I]MIP-1095 | 1095; [131I]MIP-1095; [131I]MIP-1466 | Phase 2 Clinical | Progenics Pharmaceuticals Inc | Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details |
| CONV-01-alpha + PSMA I&T | Phase 2 Clinical | Convergent Therapeutics Inc | Prostatic Neoplasms | Details | |
| LAVA-1207 | LAVA-1207 | Phase 2 Clinical | Vu University Medical Center, Lava Therapeutics NV | Prostatic Neoplasms, Castration-Resistant | Details |
| 4SCAR-PSMA T cell therapy (Shenzhen Geno-Immune Medical Institute) | Phase 2 Clinical | Shenzhen Geno-Immune Medical Institute | Lymphoma, B-Cell; Neoplasms | Details | |
| [225Ac]Ac-PSMA-R2 | [225Ac]Ac-PSMA-R2 | Phase 2 Clinical | Novartis Pharma Ag | Prostatic Neoplasms, Castration-Resistant | Details |
| 177Lu-PSMA | 177Lu-PSMA | Phase 2 Clinical | Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori | Carcinoma, Renal Cell; Neoplasms; Prostatic Neoplasms; Neoplasm Metastasis | Details |
| [177Lu]JH020002 | Lu 177 JH020002; [177Lu]JH020002; 177-Lu JH-020002 | Phase 2 Clinical | Bivision Biomedical Technology (Nanjing) Co Ltd | Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details |
| [177Lu]Lu-XT033 | [177Lu]Lu-XT033 | Phase 2 Clinical | Beijing Xiantong International Technology Co Ltd | Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details |
| 177Lu-HTK03170 | 177Lu-HTK03170 | Phase 2 Clinical | British Columbia Cancer Agency | Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details |
| Ga-68-NGUL | Phase 2 Clinical | Cellbion Co Ltd | Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details | |
| CD19/70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) | Phase 2 Clinical | Shenzhen Geno-Immune Medical Institute | Lymphoma, B-Cell; Leukemia, B-Cell | Details | |
| GD2/PSMA Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) | bi-4SCAR GD2/PSMA | Phase 2 Clinical | Shenzhen Geno-Immune Medical Institute | Solid tumours | Details |
| PSMA/CD70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) | bi-4SCAR PSMA/CD70 | Phase 2 Clinical | Shenzhen Geno-Immune Medical Institute | Neoplasms | Details |
| 177Lu-rhPSMA-10.1 | 177Lu-rhPSMA10.1; (177Lu) rhPSMA-10.1; Lutetium (177Lu) rhPSMA-10.1 (Tx IMP); Lutetium-177 rhPSMA10.1; Lutetium Lu 177 PSMA-10.1; 177Lu rhPSMA-10.1; Lu177-rhPSMA; 177Lu Radiohybrid PSMA-10.1; 177Lu-rhPSMA-10.1; 177Lu-rhPSMA | Phase 2 Clinical | Technical University Munich | Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms; Urogenital Neoplasms; Prostatic Diseases | Details |
| Lu-177-DGUL | PSMA-D GUL; Lu-177-DGUL; 177Lu-DOTA-GUL | Phase 2 Clinical | Cellbion Co Ltd | Neoplasms; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details |
| TLX-592 | TLX-592 | Phase 2 Clinical | Telix Pharmaceuticals Ltd | Prostatic Neoplasms | Details |
| 68Ga-PSMA-IRDye | TLX591-Sx | Phase 2 Clinical | Telix Pharmaceuticals Ltd | Prostatic Neoplasms | Details |
| REGN-4336 | REGN-4336 | Phase 2 Clinical | Regeneron Pharmaceuticals Inc | Prostatic Neoplasms, Castration-Resistant | Details |
| [177Lu]Ludotadipep | 177Lu-FC705; 177Lu-FC-705 | Phase 2 Clinical | Futurechem | Prostatic Neoplasms, Castration-Resistant | Details |
| 67Cu-SAR-bisPSMA (Clarity Pharmaceuticals) | Phase 2 Clinical | Clarity Pharmaceuticals Ltd | Prostatic Neoplasms, Castration-Resistant | Details | |
| ARX-517 | ARX-517; ARX517 | Phase 2 Clinical | Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details | |
| OTL-78 | OTL-78 | Phase 2 Clinical | Purdue University, Novartis Pharma Ag | Prostatic Neoplasms | Details |
| INO-5401 | INO-5401 | Phase 2 Clinical | Inovio Pharmaceuticals Inc | Carcinoma, Transitional Cell; Glioblastoma | Details |
| 225 Actinium PSMA-617 | 225 Actinium PSMA-617; 225Ac-PSMA 617; AAA 817; 225Ac-PSMA-617 | Phase 1 Clinical | Novartis Pharma Ag, Endocyte Inc, Advanced Accelerator Applications Sa | Prostatic Neoplasms, Castration-Resistant | Details |
| JNJ-63898081 | JNJ-8081; JNJ-63898081 | Phase 1 Clinical | Johnson & Johnson Innovative Medicine | Neoplasms | Details |
| P28z-CAR | P28z-CAR | Phase 1 Clinical | Memorial Sloan Kettering Cancer Center, United States Department Of Defense | Prostatic Neoplasms | Details |
| PSMA-CART cell therapy (Shanghai Bioray Laboratory) | Phase 1 Clinical | BRL Medicine Inc | Prostatic Neoplasms, Castration-Resistant | Details | |
| Autologous T-cell therapy (anti-PSMA-CD3), Roger Williams Medical Center | Phase 1 Clinical | Roger Williams Medical Center | Prostatic Neoplasms | Details | |
| CC-1 | CC-1 | Phase 1 Clinical | University Of Tubingen, German Cancer Research Center (Dkfz) | Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms; Carcinoma, Squamous Cell | Details |
| Acapatamab | AMG-160 | Phase 1 Clinical | Amgen Inc | Prostatic Neoplasms, Castration-Resistant; Carcinoma, Non-Small-Cell Lung | Details |
| 177Lu-EB-vipivotide tetraxetan | 177-Lu-EB-PSMA-617 | Phase 1 Clinical | Peking Union Medical College Hospital, National Institute For Biomedical Imaging And Bioengineering (Nibib) | Carcinoma, Renal Cell; Carcinoma, Adenoid Cystic; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details |
| [177Lu]-CTT-1403 | CTT-1403; [177Lu]CTT1403; 177Lutetium CTT1403; [177Lu]CTT-1403 | Phase 1 Clinical | Cancer Targeted Technology Llc | Prostatic Neoplasms | Details |
| Pelgifatamab corixetan | BAY-2315497 | Phase 1 Clinical | Bayer AG | Prostatic Neoplasms, Castration-Resistant | Details |
| 161Tb-SibuDAB | Phase 1 Clinical | University Hospital Basel | Prostatic Neoplasms, Castration-Resistant | Details | |
| [Ac-225]-PSMA-62 | [Ac-225]-PSMA-62 | Phase 1 Clinical | Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details | |
| JNJ-9401 | JNJ-9401 | Phase 1 Clinical | Xencor Inc | Prostatic Neoplasms | Details |
| ABBV-969 | ABBV-969; ABBV969 | Phase 1 Clinical | Abbvie Inc, Immunogen Inc | Prostatic Neoplasms, Castration-Resistant | Details |
| JNJ-87189401 | JNJ-87189401 | Phase 1 Clinical | Janssen Research & Development Llc | Prostatic Neoplasms | Details |
| Actinium-225-macropa-pelgifatamab | BAY-3546828; BAY3546828 | Phase 1 Clinical | Bayer AG | Prostatic Neoplasms, Castration-Resistant | Details |
| 177Lu-LNC1003 | 177Lu-LNC1003 | Phase 1 Clinical | Shanghai Lannacheng Biotechnology Co Ltd | Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details |
| PSMA-Targeted [In-111]-Labeled Trillium Compound | Phase 1 Clinical | Ratio Therapeutics Inc | Prostatic Neoplasms | Details | |
| Autologous T cells therapy(Unicar-Therapy) | Phase 1 Clinical | Shanghai Unicar-Therapy Bio-Medicine Technology Co Ltd | Prostatic Neoplasms | Details | |
| 212Pb-NG001 | 212Pb-NG001; AB-001; AB001 | Phase 1 Clinical | ARTBIO Inc | Prostatic Neoplasms, Castration-Resistant | Details |
| CART-PSMA cells（Nova Therapeutics） | Phase 1 Clinical | Nova Therapeutics LLC | Prostatic Neoplasms | Details | |
| 68Ga-labeled NY108 | 68-Ga-labeled NY-108 | Phase 1 Clinical | Affiliated Hospital Of Jiangnan University | Prostatic Neoplasms | Details |
| JANX-007 | JANX-007; PSMA-TRACTr | Phase 1 Clinical | Janux Therapeutics Inc | Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details |
| JNJ-80038114 | JNJ-80038114 | Phase 1 Clinical | Janssen Research & Development Llc | Prostatic Neoplasms | Details |
| CART-PSMA-TGFbRDN (University of Pennsylvania) | Phase 1 Clinical | University Of Pennsylvania | Prostatic Neoplasms | Details | |
| TNB-585 | TNB-585; AMG-340 | Phase 1 Clinical | Teneobio Inc | Prostatic Neoplasms, Castration-Resistant | Details |
| AVC-102 | AVC-102 | Phase 1 Clinical | AvenCell Therapeutics Inc | Kidney Neoplasms; Breast Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
| CBP-1018 | CBP-1018 | Phase 1 Clinical | Solid tumours; Carcinoma, Renal Cell; Prostatic Neoplasms; Lung Neoplasms | Details | |
| CCW-702 | CCW-702 | Phase 1 Clinical | The Scripps Research Institute Inc, Abbvie Inc | Prostatic Neoplasms | Details |
| Anti-PSMA CAR T-cell therapy (TNK Therapeutics) | Phase 1 Clinical | Sorrento Therapeutics Inc | Neoplasms | Details | |
| CART-PSMA-TGFβRDN cell therapy (Tmunity Therapeutics) | TmPSMA-02 | Phase 1 Clinical | Tmunity Therapeutics Inc, University Of Minnesota, University Of Pennsylvania | Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details |
| 177Lu-PSMA-0057 | 177Lu-PSMA-0057 | Nanjing First Hospital, Nanjing Medical University | Details | ||
| [68Ga]Ga-PSMA-D5 | [68Ga]Ga-PSMA-D5 | Anhui Provincial Hospital | Details |
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