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GPRC5D

GPRC5D Molecule Information

Name:G-protein coupled receptor family C group 5member D
Target Synonym:Orphan G-Protein Coupled Receptor,G Protein-Coupled Receptor Class C Group 5 Member D,G Protein-Coupled Receptor, Class C, Group 5, Member D,G Protein-Coupled Receptor, Family C, Group 5, Member D,G-Protein Coupled Receptor Family C Group 5 Member D,GPRC5
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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GPRC5D Part of Bioactivity data

GPD-H82D4-ELISA
Biotinylated Human GPRC5D, His,Avitag&Flag Tag (Nanodisc)Biotinylated Human GPRC5D, His,Avitag&Flag Tag (Nanodisc) (Cat. No. GPD-H82D4) ELISA bioactivity

Immobilized Biotinylated Human GPRC5D, His,Avitag&Flag Tag (Nanodisc) (Cat. No. GPD-H82D4) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-GPRC5D Antibody, Mouse IgG1 with a linear range of 0.002-0.313 μg/mL (QC tested).

GPD-H82D6-ELISA
Biotinylated Human GPRC5D, His,Avitag&Flag TagBiotinylated Human GPRC5D, His,Avitag&Flag Tag (Cat. No. GPD-H82D6) ELISA bioactivity

Immobilized Biotinylated Human GPRC5D, His,Avitag&Flag Tag (Cat. No. GPD-H82D6) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-GPRC5D Antibody, Mouse IgG1 with a linear range of 0.016-0.5 μg/mL (QC tested).

Synonym Name

GPRC5D

Background

G-protein coupled receptor family C group 5 member D (GPRC5D) is a retinoic acid-inducible 40 kDa protein with seven transmembrane segments and a short N terminal extracellular region. Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscle and ovary.

Clinical and Translational Updates

GPRC5D Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Talquetamab JNJ-7564; JNJ-64407564 Phase 2 Clinical Janssen Global Services Llc, Genmab Hematologic Neoplasms; Multiple Myeloma Details
MCARH-109 Phase 1 Clinical Memorial Sloan Kettering Cancer Center Multiple Myeloma Details

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