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Your Position: Home > Pseudovirus Neutralization Antibody Assay Service

Pseudovirus Services

Pseudovirus Services
What are Pseudoviruses?

Pseudoviruses are virus particles that have altered nucleic acid sequences within their genome to ensure they are replication-deficient and non-pathogenic. These particles mimic viruses by expressing key proteins on the envelope, which is a key factor in defining a virus’ infectious characteristics. However, the gene modifications enable them to be biologically safe to handle in most laboratories. As such, pseudoviruses are designed to be a substitute for live viruses when evaluating neutralizing antibody production and viral entry inhibition. There are several advantages when using pseudoviruses: Safe, Effective & Flexible; No BSL-3/4 Laboratories Required; High throughput & Quantitative studies.

ACROBiosystems is closely monitoring the development and research status of various viruses and infectious diseases. As such, we currently offer a wide range of reporter pseudoviruses for enveloped and non-enveloped viruses, alongside our pseudovirus research-related technical services.
We offer services including:

Screening & Evaluation of antibodies and other antivirals

Neutralizing Antibody Assays

Vaccine Efficacy assessments for the development of vaccines, diagnostics, and therapeutics

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Pseudovirus Technology Platform
Principle
Screening Study Workflow
Pseudovirus Service Scope
Pseudovirus TypeAssociated Viral DiseaseSubtype / Serotype
HPV
HPV
Multiple benign tumours or warts, cancer6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68

RABV
RabiesCVS-11

SARS-CoV-2
Novel coronavirus pneumoniaWT, D614G, Alpha, Beta, Gamma, Delta, Delta plus, Lambda, Mu, BA.1, BA.2, BA.2.12.1, BA.2.75, BA.3, BA.4 & BA.5, BF.7, BQ.1.1, XBB.1, XBB.1.5

SARS-CoV
Severe Acute Respiratory SyndromeWT

MERS-CoV
Middle East Respiratory Syndrome (MERS)WT

Nipah virus
Nipah Viral EncephalitisMY

Ebola virus
Ebola virus disease (EVD)Zaire

SFTSV
Fever with thrombocytopenia syndromeHB29

Influenza virus
Influenza (flu)H1N1

VSV
Blistering StomatitisIndiana
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We also offer a pseudovirus custom service.
Service details
Sample TypeNeutralizing antibodies, drugs, serum samples, etc. are all acceptable.
Detection ReagentACROBiosystems provides the other materials needed! This includes target cells, pseudoviruses, luciferase detection reagents, etc.
Detection InstrumentPerkinElmer EnSight Microplate Reader
Quality Standard1. Average pseudovirus luciferase intensity compared to average cell control luciferase must be larger than 1000.
2. Background intensity of pseudovirus luciferase is less than 3%.
DeliverablesProject report
Service Period2-4 weeks
Case studies
Neutralization activity of sodium heparin at 37°C was evaluated using HPV type 16 pseudovirus
Neutralization activity of sodium heparin at 37°C was evaluated using HPV type 16 pseudovirus
Neutralization activity of three antibodies at 37°C was evaluated separately using SARS-CoV-2 (WT) pseudovirus
Neutralization activity of three antibodies at 37°C was evaluated separately using SARS-CoV-2 (WT) pseudovirus
Neutralization activity of three antibodies at 37°C was evaluated separately using SARS-CoV-2 (Omicron BA.1)
Neutralization activity of three antibodies at 37°C was evaluated separately using SARS-CoV-2 (Omicron BA.1)
Advantage

High stability: The method has high stability and the results are true and reliable.

High specificity and sensitivity: High-quality pseudovirus, high-sensitivity detection equipment recognized by the industry.

High-quality detection model: Highly simulating the physiological infection mechanism, which can simulate the actual treatment effect to the greatest extent.

Efficient and fast :The project team will follow up the project one-on-one, give you feedback on the progress of the project periodically, and deliver the experimental results in time.

Extensive service experience and excellent attitude : Outstanding technical service experience, and customized personalized experimental strategies in close linkage with customers.

Service flow

Inquiry and order

  • ACROBiosystems scientist will respond within 24 hours of submission.

  • Call us at: +1 800-810-0816 or email at services@acrobiosystems.com for consultation.

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Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA

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